Foresight by the editors of Heredity in 1965 putting papers on scrapie and [PSI+] back-to-back

📣 WE ARE HIRING (TT assist. or assoc. prof) Come be my colleague at the University of Copenhagen 🇩🇰! Copenhagen is a great city to live in 🚲🌤️ 👪 and you will have lots of great colleagues 🧑‍🔬🧑‍💼 working on diverse topics🧪🧫🧶🍝🧬🖥️ Deadline Sept 22: employment.ku.dk/faculty/?show=…

Proteins are famous for folding into stable shapes, but ~1/3 of them have parts that are much...floppier 🍝 new research by Francesco Pesce and Kresten Lindorff-Larsen presents a method to design these disordered regions that could open the door for new drugs! fiercebiotech.com/research/contr…

It was fun to play a small role in this awesome work! Congratulations to Francesco Pesce and Kresten Lindorff-Larsen and thank you for SJ colleagues Anne Bremer and (Christy) Grace Royappa and all other authors for their wonderful work!

Read also the commentary "Extending computational protein design to intrinsically disordered proteins" by Paul Robustelli 🙏 #ScienceAdvancesResearch doi.org/10.1126/sciadv…

Very cool step towards designing the "unstructured".

I'm excited to share a perspective I wrote in Science Advances on an exciting new paper from Francesco Pesce Kresten Lindorff-Larsen and TanjaMittag on computationally designing IDR sequences with desired properties. Paper: science.org/doi/10.1126/sc… Perspective: science.org/doi/10.1126/sc…

While I can't objectively rank our work against that of other teams it is easier to rank different projects from our group in my perception of value to others. This perception quite a lot of times does not match how it is received by editors/reviewers.

Mikhail Spivakov It is the lottery of the editors/reviewers which averages out over a number of projects/papers but has a disproportionate impact on the key project leaders

“Dynaformer, trained on MD trajectories of 3,218 protein-ligand complexes, captures the full thermodynamic ensemble” 🤪

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/

Introducing Neural Electron Real-space Density (NERD) models! 🧠 You’ve solved the electronic Schrödinger equation using PauliNet or Psiformer - what next? Important properties come from the 1-electron density (the marginal #MachineLearning) arxiv.org/abs/2409.01306

Klassisk arkæolog Rubina Raja og biokemiker Jesper Qualmann Svejstrup får overrakt #CFforskpris 2024 for deres banebrydende forskning gennem en lang flot karriere - KÆMPE tillykke med prisen 👏👏 bit.ly/cfforskpris24 #dkforsk

Our MDverse paper is now published in its final form in eLife - the journal ! 🥳 It was a great collab & lot of fun to work with Pierre Poulain and Johanna Tiemann 🙏 Erik Lindahl - eriklindahl.bsky.social , Kresten Lindorff-Larsen , Lucie Delemotte , Marc Baaden and co! doi.org/10.7554/eLife.…

What would you rather have? AlphaProteo white paper as is. Or AlphaProteo paper in Nature with pseudocode and a webserver but no code (AF3 style)