Sleebs Lab
@sleebs_lab
Medicinal Chemistry and Chemical Biology Research Laboratory @WEHI_research #cancer #malaria #infectiousdiseases | views are our own
ID: 1473143662515081216
https://www.wehi.edu.au/people/brad-sleebs 21-12-2021 04:10:42
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Pleased Sleebs Lab WEHI (Walter and Eliza Hall Institute) contributed to the preliminary research that led to BNC210 that has had promising outcomes in clinical trials for treatment of anxiety disorders. sciencedirect.com/science/articl…
Pleased Sleebs Lab WEHI (Walter and Eliza Hall Institute) contributed to research led by Harrison Shanley University of Melbourne on early stage optimisation of a nematicidal chemotpye with potential use in the agriculture industry. sciencedirect.com/science/articl…
Pleased at Sleebs Lab WEHI (Walter and Eliza Hall Institute) has contributed to research led by Swapna Varghese Monash Institute of Pharmaceutical Sciences on anti-trypanosomal compounds with a unique metabolome profile sciencedirect.com/science/articl…
Pleased Sleebs Lab WEHI (Walter and Eliza Hall Institute) contributed to research led by Harrison Shanley University of Melbourne describing screening efforts to identify a new nematicide class with potential use in the live stock industry. link.springer.com/10.1186/s13071…
Pleased Sleebs Lab WEHI (Walter and Eliza Hall Institute) contributed to research led by Harrison Shanley University of Melbourne describing preliminary optimisation of a new nematicide class with potential use in the live stock industry. sciencedirect.com/science/articl…
Glad to see our research is published which was led by William Nguyen Sleebs Lab WEHI (Walter and Eliza Hall Institute) describing the activity refinement of aryl amino acetamides that target the P. falciparum lipid transfer protein PfSTART1 sciencedirect.com/science/articl…
Congratulations to Harrison Shanley Sleebs Lab for a fanastic PhD completion seminar. A huge embodiment of research on the discovery nematicides with potential application in the livestock industry.
Excited to share our new study in Nature Communications. We found that M-833 blocks Pf ring development by targeting a lipid-transfer protein PfSTART1. This breakthrough could open new avenues for malaria treatment! Read 🧵below: WEHI (Walter and Eliza Hall Institute) BurnetMalaria (1/8) nature.com/articles/s4146…
Will Nguyen Sleebs Lab did some nifty medicinal chemistry and hugely improved the potency of the series getting the EC50 down to the low nanomolar range- in line with current antimalarials! (4/8)
New treatments are needed as #malaria becomes resistant to current drugs. Research from Madeline Dans Sleebs Lab + team at WEHI & Burnet Institute finds PfSTART1 is a promising new protein target. Read the study in Nature Communications: doi.org/10.1038/s41467…
Pleased that our article led by Petar Calic Sleebs Lab WEHI (Walter and Eliza Hall Institute) working with Medicines for Malaria Venture (MMV) is published, describing the discovery and optimization of a new scaffold with potent antimalarial activity. sciencedirect.com/science/articl…
.Sleebs Lab WEHI (Walter and Eliza Hall Institute) have refined the properties of a PfATP4 targeted antimalarial to exhibit efficacy in malaria mosquito and mouse models. #JMedChem go.acs.org/asr
Pleased that research led by Sleebs Lab WEHI (Walter and Eliza Hall Institute) on optimization of a PfATP4 targeted antimalarial with curative and transmission blocking potential has been published. pubs.acs.org/doi/10.1021/ac…