ctDNA improves prognostic prediction in relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone ashpublications.org/blood/article/…

scratch-work-2af.notion.site/ad4cf9c6d73f49…

Read the recent study being discussed at #AACR24 Project GENIE session: Pan-Cancer Comparative & Integrative Analyses of Driver Alterations Using Japanese & International Genomic Databases. bit.ly/3U9napO Sara Horie Yuki Saito Keisuke Kataoka Laboratory（片岡 圭亮 研究室） 国立がん研究センター研究所 NCCRI Japan Official Account 国立がん研究センターがんゲノム情報管理センター（C-CAT）

Happy to share our collaborative work out in AJHG. We have demonstrated that FDFT1 gene promoter methylation mosaicism is associated with the development of skin lesions in porokeratosis, a keratinization disorder characterized by pre-malignant clonal skin lesions.

【注目プレスリリース】皮膚病の要因となるエピゲノム異常を初めて発見 －汗孔角化症の新しい発症メカニズムと原因遺伝子を解明－ / 神戸大学 research-er.jp/articles/view/…

.Yuki Saito et al. report in AJHG's latest article that mosaic epigenetic silencing of FDFT1 causes non-hereditary porokeratosis, predisposing specific skin areas to the disease: cell.com/ajhg/abstract/… #ASHG #GeneticsDiscoveries

Pan-cancer comparative and integrative analyses of driver alterations using Japanese and international genomic databases [Jan 26, 2024] Sara Horie Yuki Saito Keisuke Kataoka Laboratory（片岡 圭亮 研究室） et al. Cancer Discovery bit.ly/490njke #PrecisionMedicine #globonc 国立がん研究センター研究所 NCCRI Japan Official Account 国立がん研究センターがんゲノム情報管理センター（C-CAT）

A paper in nature reports on the ability of AlphaFold 3 to produce accurate predictions of the structures of proteins interacting with other biological molecules. AlphaFold 3 demonstrates substantially better accuracy over previous specialist tools. go.nature.com/44CAnev

Now online in Cancer Discovery: Identification of #ClonalHematopoiesis Driver Mutations through In Silico Saturation Mutagenesis - by Santiago Demajo, Joan Enric Ramis-Zaldivar, abeldavidgp, Nuria Lopez-Bigas and colleagues doi.org/10.1158/2159-8… bbglab @irbbarcelona CIBERONC

Understanding the complexity of p53 in a new era of tumor suppression p53が発見されて45年ですが、Cancer Cell誌に非常によくまとまったp53の総説が発表されました。 cell.com/cancer-cell/fu…

Trastuzumab deruxtecan in HER2+ gastric cancer Nature Medicine doi.org/10.1038/s41591… 🔎exploratory biomarker analysis of DESTINY Gastric01 👉64% concordance btw HER2+ IHC & 🩸 👉MET, EGFR & FGFR2 GA: ORR⬇️ 👉HER2 mutations: ORR⬆️ 👉activity in Her2 low ESMO - Eur. Oncology

New from the May issue— Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases, by Sara Horie, Yuki Saito, Keisuke Kataoka Laboratory（片岡 圭亮 研究室） et al. bit.ly/3V0R0NP 国立がん研究センター研究所 NCCRI Japan Official Account 国立がん研究センターがんゲノム情報管理センター（C-CAT）

Rstudioみたいな感じでPythonコードが書けるのすごく良いね

New in Cancer Landscapes from the July 1 issue— Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma, by Yuta Ito et al. bit.ly/3VZ9ttn Keisuke Kataoka Laboratory（片岡 圭亮 研究室）

‼️ The final version of our article “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out in Cancer Discovery Cancer Discovery: aacrjournals.org/cancerdiscover… Learn more about our findings in this thread 👇🏽