🤔Do rheumatoid factor, anti-citrullinated protein antibodies or shared epitope associate with clinical response to initial treatment in #RA? 🚫Unfortunately not! ✔️but #abatacept better response in #RF/#ACPA-positive at 24 weeks ❌but not at 48 weeks😒 ard.bmj.com/content/early/…

📣New insights in the #complement system in #IgG4-related disease! ☝️Complement activation was not organ-specific 👉 Serum IgG1 concentrations independently associated with hypocomplementaemia Read the whole story here: ard.bmj.com/content/early/…

👍examination of plasma proteins in giant cell arteritis! ✔️537 proteins different between active GCA and controls ✔️781 between inactive GCA and controls ✔️16 proteins associated with disease activity ❌limited use to distinguish active and inactive☹️ ard.bmj.com/content/early/…

☝️ Sequential lymph node biopsies after #CD19-CAR T-cell therapy: 🔹CD19+, CD20+ cells, follicular DC completely depleted after CD19-CAR T-cells, but not after #rituximab 🔹Follicular structures disrupted 🔹Plasma cells, T cells and macrophages unchanged ard.bmj.com/content/early/…

Efficacy & safety of sequential therapy with SC #belimumab & one cycle rituximab in #SLE 🔷 Ph3 RCT BLISS-BELIEVE study 🔷 BEL/PBO vs BEL/RTX 🔷 263 pts 🔷 SLEDAI-2K 👉 16.7% vs 19.4% achieved disease control (OR 1.27; p=0.5342) at wk 52 🔗 bit.ly/3yIp21e

FOREMOST is the first RCT designed for early oligoarticular PsA 🔎 308 pts randomised: apremilast 203; PBO 105 🔷 Mean (SD) PsA duration 9.9 (10.2) months 🔷 Primary endpoint: MDA sentinel joints at week 16 👉 Apremilast 33.9% vs PBO 16.0%, p=0.0008  🔗 bit.ly/3yVOUqk

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development 🔷 Study in PU.1-T cell-conditional knockout (KO) mice, IL-9 KO and IL-9R KO mice 👉 Targeting this signalling axis presents a potential target approach for treating RA 🔗 bit.ly/4cGJDk7

Safety & efficacy of #tofacitinib in juvenile idiopathic arthritis 🔴 Preliminary results of open-label, long-term extension study 🔷225 patients 🔺10 serious infections 🔺3 herpes zoster 🔺2 uveitis 🔷JIA-ACR70/90 response 60.0% & 33.6% at month 1 🔗 bit.ly/4dF0iWz

Higher RA disease activity associated with accelerated eGFR decline 🔷 Data from a large prospective registry study 🔷 31129 patients (median age: 58.0 years) ⬆️ Adjusted HRs for CKD stage G3a/b in low, moderate & high disease activity vs remission 🔗 bit.ly/3X26GjF

Low uveitis rates in patients with axial spondyloarthritis treated with #bimekizumab 🔎 Pooled results phase 2b/3 trials BE MOBILE 1 & 2 🔴 0.6% (2/349) of patients receiving BKZ experienced uveitis vs 4.6% (11/237) PBO (p=0.001) ❓ Protective effect? 🔗 bit.ly/3AD6xMf

Relationship between serum urate and changes in DECT monosodium urate crystal volume over 1 year in #gout 🔎 Individual participant data analysis 💠 MSU crystal dissolution (DECT) ↔️ SU <0.29 mmol/L 💠 MSU crystal formation ↔️ SU ≥0.48 mmol/L 🔗 bit.ly/3X4SaYo

Serum from patients with idiopathic inflammatory myopathy induces skeletal muscle weakness 🔎 Humanised ex vivo experimental platform 🐭 Muscles from healthy mice exposed to sera from 8 IIM pts ▶️ Force production ⬇️ across stimulation frequencies 🔗 bit.ly/3TcltY9

Check out Robert Landewé & Maarten Boers' #correspondence on ‘Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis’ by Kim et al. #bigdata 🔗 bit.ly/3yPNvBP

Optimal serum urate concentrations for MSU crystal dissolution in #gout? Check out the latest findings using a #DECT approach: ▶️crystal dissolution: <0.24 and 0.24-0.29 mmol/L ▶️crystal formation: >0.48 mmol/L 🔗 bit.ly/3X4SaYo

Interested in renal function in #rheumatoid #arthritis? Check out our latest publication from a large registry 🇺🇸 ▶️high disease activity linked to accelerated glomerular filtration over time ▶️disease activity linked to CKD onset (G3 stage) 🔗 ard.bmj.com/content/early/…

What is the link between PU.1 transcription factor and IL-9 in #rheumatoid arthritis? 🔄 PU.1 promote Th9 differentiation in a positive feedback loop: ▶️PU.1 activates IL-9 transcription ▶️IL-9 induces PU via Jak/STAT 🔗 bit.ly/4cGJDk7

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Check out our latest #Images in rheumatology section: 👁️ More than meets the eye ▶️exophthalmos and consecutive diplopia ▶️pseudotumour suspected ▶️positive for anti-PR3 antibodies ▶️biopsy confirmed small-vessel vasculitis 🔗 bit.ly/3X8uvGv

How can #artificialintelligence assist in #osteoarthritis care? ▶️ new tool predicts OA progression ▶️ identification of key predictors: #PROs and #MRI features ▶️ transparency facilitates clinical adoption 🔗 bit.ly/3XyA1nv

How to target #FLS in #rheumatoid #arthritis? Check out our latest publication on the use of #aptamers: ▶️ aptamers selectively targeting FLS were developed ▶️ #nucleolin as autoantigen ▶️ aptamer treatment relieved #arthritis in mouse model 🔗 bit.ly/3My3U0N