Florence Nightingale, born #OnThisDay in 1820, is best known as the ‘lady with the lamp’ and the founder of modern nursing. She was also a brilliant statistician and pioneered the use of data visualisation. #WomenInSTEM bit.ly/3WeBwHc

Excited to share Albert Escobedo's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with Andre Faure @[email protected] Centre for Genomic Regulation (CRG) Wellcome Sanger Institute biorxiv.org/content/10.110…

Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new Royal Society Publishing biographical memoir: royalsocietypublishing.org/doi/10.1098/rs…

We have a tenure track opening for a computational scientist with exciting ideas for #machinelearning in molecular biology at the MRC Laboratory of Molecular Biology, incl generous core funding from Medical Research Council & an unparalleled scientific environment. RTs appreciated! 🤗 jobs.sciencecareers.org/job/657824/res…

Our team in #Barcelona is expanding & we're #hiring 2 talented scientists to fill these exciting new positions: a Lead Scientist & a Research Associate. Do u want to make a real difference in the future of applied high-throughput genetics and therapeutics? #PhdChat #ScienceJobs

Pleased that the first preprint from my lab is on bioRxiv today! CelEsT - a unified and benchmarked gene regulatory network for estimating transcription factor activity in my beloved C. elegans biorxiv.org/content/10.110…

Good job. Nice city.

Search for a new CRG director has made me reflect on one of the structural problems of spanish/catalan science: directors who cling onto their positions for decades. If all leadership positions were limited to 10 years, Spanish science would be much stronger.

Great article in EL PAÍS by Manuel Ansede “Can you be a director for so long without creating bad habits and bad practices?”

Interpretably deep learning amyloid nucleation by massive experimental quantification of random sequences new preprint by Mike-no twitter-Thompson with Mariano Martín, Peter Koo and Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC biorxiv.org/content/10.110…

"Shall we just try this on random sequences?!" "Yes we shall". A couple of years and 100K sequences later...🙂

One more week to apply for the Lead Scientist position at ALLOX! 👉 allox.bio/careers/lead-s… At ALLOX, we're systematically mapping all allosteric sites in disease-causing proteins to enable and accelerate the development of novel, safer, and better treatments.

Presenting the first large-scale measurement of energetic couplings for a protein transition state! biorxiv.org/content/10.110… with Anna Arutyunyan Mireia Seuma Andre Faure @[email protected] & Ben Lehner

Very, very happy to finally share this: Energetic portrait of the amyloid beta nucleation transition state Anna Arutyunyan Mireia Seuma Andre Faure @[email protected] Benedetta Bolognesi Wellcome Sanger Institute Centre for Genomic Regulation (CRG) IBEC biorxiv.org/content/10.110…

Passionate about AI + Proteins? We are hiring deep-learning scientists at all levels. We are in a privileged location with extensive resources. Junior or senior, if this resonates with you, apply now! recruitment.crg.eu/content/jobs/p…

We are looking for a computational PhD student to take lineage tracing in human to the next level. Read our preprint biorxiv.org/content/10.110… and the job ad recruitment.crg.eu/content/jobs/p…

Ignasi Ignasi Toledano paper now out in Nature Genetics! "Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules" Deep mutagenesis used to study which mRNA sequence contexts promote🛑mut rescue by🧪 Great collaboration w/Ben Lehner lab

A much improved version of this, today out in Nature Genetics ! with Ben Lehner and Fran Supek nature.com/articles/s4158…