This study from Dr Tsz Kin NG and colleagues from The Chinese University of Hong Kong The Chinese University of Hong Kong - CUHK revealed the activation of cellular senescence in rodent retina post-optic nerve injury and contribute to retinal ganglion cell survival regulation. Senolytics and TGF-β receptor

In this work, authors have identified a novel molecular pathway in which elevated levels of LCN2 enhances the expression of LDHA by activating Akt and hypoxia inducible factor-1 alpha (HIF-1α) signalling. This leads to a switch from glucose metabolism to aerobic glycolysis,

Welcome to join the 11th HOPE Young Scientist Forum online at 21:00 (GMT-4) on July 26 via Tencent Meeting meeting.tencent.com/dm/ZRRqfEjHrk7S Host: Prof. Changmei Liu Speakers: Dr. Jianyu Li Li Jianyu 李剑宇 Dr. Weimin Zhang Weimin Zhang Dr. Xiaoyu Chen Xiaoyu Chen Qi Gu Jinglei Zhai, 晶磊 翟

A new methods to visualise microRNA in situ😀: This method not only demonstrates improved sensitivity compared to traditional FISH techniques but also offers enhanced imaging resolution.

This study identified a crucial role for Rev-erbα in the pathological progression of Intervertebral discs (IVDs) degeneration. Rev-erbα deficiency aggravates nucleus pulposus (NP) cell apoptosis and imbalance of extracellular matrix. onlinelibrary.wiley.com/doi/full/10.11…

This work showed that the depletion of Eif2s2 in premeiotic germ cells impaired the translation of proteins related to HR and mitochondrial fission. These impairments resulted in oocyte meiotic arrest at the early diplotene stage and eventually led to the apoptosis of oocytes and

Very informative, thank you！

This review article highlights the angiogenesis properties of endothelial progenitor cells as valid cell sources for the induction of angiogenesis using various tissue engineering modalities. The application of different substrates with several synthesis protocols was also

This study establishes a wound-induced skin fibrosis mouse model and demonstrates that TGFβ-mediated blockage of HI-AP differentiation is crucial for driving fibrotic pathology. Targeting HI-APs and adipogenesis may provide novel avenues for developing disease-modifying therapies

This study established a simple yet effective small molecule drug for Retinal ischemia/reperfusion injury (RI/R) treatment which may become a promising neuroprotectant for treating this type of vision impairment disease in the future. onlinelibrary.wiley.com/doi/10.1111/cp…

This review examine the history and most current developments in brain, gut, and gut-brain chips. The importance of these systems for understanding pathophysiology and developing new drugs is emphasized throughout the review. onlinelibrary.wiley.com/doi/10.1111/cp…

This review describes the mechanisms of immune cell-mediated inflammatory responses in the course of ischemic heart disease from macroscopic and microscopic perspectives, explains the mechanisms of macrophage-induced activation of fibroblasts during the repair phase, and

A big congratulations!🥳

This study has provided a reliable approach for generating large-scale and cryopreserved mesothelin (MSLN) CAR-NK cells from human embryonic stem cells (hESCs) as an alternative cell source. The thawed MSLN CAR-NK cells immediately recovered after 48–72-h culture and effectively

A review of the key role of HDAC3 in the process of inflammation, the potential molecular mechanism and the clinical significance of targeted therapy. HDAC3, a member of the histone deacetylase (HDAC) superfamily, is involved in the regulation of acetylation/deacetylation

This work evaluated the role of cytoskeletal elements MF (Microfilaments) and MT (microtubules) in mechanical stress-induced autophagy using fluorescence imaging and biochemical techniques. The data support that microfilaments are core components of mechanotransduction signals.

In the study, researchers found that downregulation of CDX2 during implantation is a prerequisite for human trophoblast cell fusion. onlinelibrary.wiley.com/doi/10.1111/cp…

This interesting finding demonstrate the potential of alternating electric fields (AEFs) as a therapeutic modality to impede angiogenesis and restrain cancer growth. The application of 1000 kHz alternating electric fields effectively suppresses tumour vasculature, transforming it

This study from Prof Lijun Wu at Anhui University, and Prof Jianping Fu Jianping Fu at University of Michigan shows that small molecule valproic acid enable the generation of more reproducible, ventrally self-patterned hNTOs, in which floor plate and pMN domains were spatially

This is amazing work and visualization!!