Recruitment! We are looking for a candidate for the lab (postdoc or scientist) with experience in yeast and/or phage display to work on some cool bioengineering projects for immunotherapy development! Please reach out if interested! Science friends, please retweet!

Hi #EACR2024! Today I'm presenting our results on prostate cancer #heterogeneity and the role of PKA in osteopontin regulation during bone #metastasis. This work was done at Geraldine Gueron's lab IQUIBICEN - CONICET - UBA in collaboration with MD Anderson Cancer Center. See you at Poster #367 🙌 EACR

Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in Nature Communications. nature.com/articles/s4146… 🧵

Not one, but TWO of my favorite #AACRAMC colleagues are recipients of the 2024 Burroughs Wellcome Fund Postdoctoral Diversity Enrichment Program awards. Congratulations Bianca Islam, MD, PhD, MSc (she/her) and Greisha L. Ortiz-Hernández, Ph.D. 🥳 bwfund.org/news/announcin…

Breaking up the CD8+ T cell: Treg pas de deux dlvr.it/T8J4Yd

The evolution of our understanding

Weekend read: We are discussing the future of AI in cancer research in Cancer Cell sciencedirect.com/science/articl… ... with Moritz Gerstung James Zou Marzyeh Diego Chowell Jonas Teuwen Faisal Mahmood 🤩 Nationales Centrum für Tumorerkrankungen Dresden @nct_hd DKFZ Universitätsklinikum Heidelberg TU Dresden

Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton dlvr.it/T8P3RM

"We propose the creation of a new entity, the Pediatric Advanced Medicines Biotech, to lead late-stage development and commercialize pediatric CGTs outside the traditional biopharmaceutical model" Bold new ideas from Mackall Lab et al to bring life-saving cell therapies to kids.

June Society for Immunotherapy of Cancer #JITC Reading List by Section Editor Claudia Palena National Cancer Institute Selection #4: Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers by BioNTech SE, Mainz University bit.ly/3VPHsG2

Tips and tricks for building a good paper: what editors want (1/5)

I particularly like this paper: Demonstrating (1) The power of perturbing a cell-subset to understand the cell-cell interactions in the TME. (2) Using mouse derived signatures to query human clinical data and (3) Using gene programs to suggest combinatorial therapy approaches.

The mantra that spatial transcriptomics is about location, location, location is catchy, but what does it really mean? We have just posted biorxiv.org/content/10.110…, work of Kayla Jackson et al., that describes the concordex method for identifying spatial homogeneous regions. 1/🧵

In the past, I have avoided posting such preprints. However, in this case, the authors did not budge (the key first author having no computational training) and the damage to the community from using this seriously flawed pipeline would be immense. In service to the community:

Highlights from National Cancer Institute Commitment to Advancing Cancer Training from Oliver Bogler: 💸salary/stipend increases for trainees 🧑‍🍼childcare subsidies for trainees ⏩impact of transition funding 🏘️new award focused on community oncology tinyurl.com/3xkefwmt

CAR T cell combination therapies to treat cancer dlvr.it/TBwmGl

Spatial omics have lit up life science and this new review Cell is the best I've seen cell.com/cell/fulltext/… open-access

Our new arXiv paper: We built a generative AI model of blood glucose levels from 10 million continuous glucose monitoring measurements of 11,000 people from the Human Phenotype Project We show that our model can predict clinical parameters such as liver-related parameters, blood

New article from katherlab in Nature Medicine: large language models for interoperability in healthcare 👇

1st Anniversary of the AACR Global Scholar Alumni Committee #GSAC!!!🎉🥳 #AACRGlobalScholars Here's a brief summary of what we've been doing to promote #scientific and professional #development events and resources for #GSITA alumni around the world 👇 aacr.org/blog/2024/08/2…