We benchmarked 8 scATAC-seq data processing pipelines for their performance in clustering, predicting gene activities, and integrating with scRNA-seq. Check our Genome Biology paper if you want to know how to better analyze your scATAC-seq data! doi.org/10.1186/s13059…

Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (Ralph Grand) and Marco (Marco Pregnolato) now out in Molecular Cell authors.elsevier.com/sd/article/S10…. 1/7

How do you survive the HOW domain ? That’s tough!

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I’m always a bit skeptical of reports of important functions for these oxidized methylcytosine derivatives because they are so scantly distributed, and their turnover is high. But this looks pretty intriguing here

Evidence from omics that aging is not a gradual, linear process. The new study, highlighted here, only assessed people up to age 75 among 108 participants with short term follow-up (1.7 yrs). A previous large study (N>4,200, up to age 95) found a 3rd peak at age 80.

#Testosterone modulates #sexdifferences in #Immune response by functional attenuation of type-I interferon in pDC and monocyte while increasing TNF IL6 IL15 and downstream NFkB activation and potentiating interferon-γ responses in NK nature.com/articles/s4158…

Bad partners pursue their interests at your expense. They'll hurt you if it helps them. Good partners value your interests as much as theirs. They strive for win-win. Great partners internalize your interests as theirs. They take pride in your success and joy in your happiness.

Skipping through a resistance continuum How do cancer cells adapt to drug treatments?💊 nature, Itai Yanai Gustavo França &al show that cancer cells transition through a trajectory of epigenetically diverse states, progressively increasing fitness & drug resistance #sciart🧵

My favorate piece of my postdoc work is published! We fused our favorite TFs with a deaminase domain that induces point mutations in DNA, mutagenizing TF binding sites across the genome. Will be a great reagent for exp. evo., as its name suggests :) academic.oup.com/mbe/article/41…

Hallmarks of regeneration: Cell Stem Cell cell.com/cell-stem-cell…

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#Writing has always been my favourite part of research as it marks the beginning and end of a project (Hope and more Hope) and it is probably the most useful thing as a #NewPI improvement by trial and error is also something to be proud of

“That’s the way we’ve always done it” is not a justification. It’s a lazy excuse for failing to evolve. Blind faith in traditions makes us prisoners of the past. Routines should be based on present value and future potential. A key to new growth is questioning old habits.