Want to capture both transient and sustained changes of neuromodulator levels? Want to compare neuromodulator dynamics at high resolution across animals and extended periods? Happy to share our new finding on bioRxiv: tinyurl.com/bdf7ny7s (1/8)

Looking VERY much forward to our symposium @efic_org #EFIC2023 with Matthew Banghart Matt Banghart & Jane Ballantyne: MAKING THE BEST USE OF ENDOGENOUS OPIOIDS TO RELIEVE PAIN See you in Budapest in September '23!

Neuropeptides revealing their secrets! Substance P release with Matt Banghart and team. A big shout out to Scientifica for the setup.

#EBPS2023 Parallel sessions 4: Time to continue our session highlights; Titikola Akintola and Luana Colloca, MD, PhD, MS chair the session "Placebo effects: from basic mechanisms to clinical applications" with talks from Matt Banghart, Loren Martin, @colloca_luana and Ulrike Bingel

⚡️NEW OPIOID VIRAL TOOL⚡️ Lead by Greg Salimando, Ph.D. in collab with Karl Deisseroth We developed a catalog of mu-opioid receptor promoters (MORp) for viral access to endogenous opioid-expressing cell types 🦠🧠🐁🐀🐒 nature.com/articles/s4146… 🧵for more info on use & where to order:

Very cool new work from Matt Banghart on opioid circuits from PAG —> LC in PAIN modulation !!! 🐁🧠⚡️ biorxiv.org/content/10.110…

Nice work Matt and Co! Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation biorxiv.org/content/10.110… Matt Banghart et al.

Grass Fellowships at the MBL support investigator-designed, independent research projects by early-career scientists. Summer 2024 applications due December 1. go.mbl.edu/Grass

"In vivo photopharmacology with light-activated opioid drugs" Neuron Matt Banghart cell.com/neuron/fulltex…

Exciting set of new opioid tools!

New tools from my lab. Due to Minju Jeong's extensive efforts to validate the tools and Jun-Hyeok Choi's ingenious molecular design, we can now present additional methods to identify and modulate specific neuronal populations. cell.com/neuron/fulltex…

⚡️🧠Thrilled to share our new preprint on pain-related valence cell-types + circuits — A nociceptive amygdala-striatal pathway for chronic pain aversion Check out the stellar work of Jessica Wojick, in a co-senior collab with KorbLab biorxiv.org/content/10.110… THREAD 1/13

Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to control goal-directed action biorxiv.org/cgi/content/sh… #biorxiv_neursci

What an amazing experience teaching at the Neurobiology Course course with stellar students Aria Walls and Anna Brennan! Huge thanks to MBF Bioscience for loaning us the Neurophotometrics V2 fiber photometry system, which worked perfectly with our UV laser for in vivo photopharmacology.

Synapses and Circuits 2024! Thank you for a great section!! Aizenman Lab Matt Banghart Michael Higley 🧠🌈🔬 Laura Cocas watanabe lab 🔬 Juan Angueyra

1/6 Exciting news! Our paper is now online in Cell! We've developed PRESYNAPTIC sensor and silencer for peptidergic transmission. The sensor detects LDCV release events, and the silencer specifically degrades neuropeptides inside the LDCV. authors.elsevier.com/a/1jTSjL7PXqREw