Protein synthesis is key to memory but not transmission(?). Yet nature is full of surprises! We found & resolved how axonal translation is needed for burst transmission, which is crucial in memory formation. Neuron 👇Alanna Watt Jesper Sjöström @pjsjostrom.bsky.social tinyurl.com/4ybekxzs

Localized synthesis of molecular chaperones sustains neuronal proteostasis biorxiv.org/content/10.110…

blood vessels help nerve repair Structured wound angiogenesis instructs mesenchymal barrier compartmen... sciencedirect.com/science/articl…

It took 4+ years to build this 3D map of the developing human head, the most complex part of our body sciencedirect.com/science/articl… Tissue clearing #Lightsheet #VirtualReality #3D models & More! Congrats to Raphael Blain, E. Shotar G. Couly Yorick Gitton, Human in 3D et al. video summary 🔊

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy | bioRxiv biorxiv.org/content/10.110…

Lifelong persistence of nuclear RNAs in the mouse brain | Science science.org/doi/10.1126/sc…

Beautiful work- congrats Ezgi Hacisuleyman! nature.com/articles/s4159…

Excited to share our paper by Raffaella De Pace Saikat Ghosh et al. showing that BORC-dependent transport of lysosomal vesicles into the axon is crucial for the axonal movement of a large cohort of mRNAs, mainly those encoding ribosomal and mitochondrial proteins nature.com/articles/s4159…

🧠 Get ready for the October #BrainConference! 🧬 Join renowned chairs Drs Erin Schuman, Giovanna Mallucci and Emily Osterweil and delve into neuronal #ProteinSynthesis mechanisms. 📅 Register by 14 May: loom.ly/xdcmHRQ @Lundbeckfonden The Brain Prize Erin schuman

Happy to share our mini review in COCEBI written by Mai Dan Nguyen together with Ginny Farias and me. We highlight the exciting emerging role of contacts between the endoplasmic reticulum and membrane-less organelles in protein synthesis and secretion. authors.elsevier.com/sd/article/S09…

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons | bioRxiv biorxiv.org/content/10.110…

Wow

Online now: Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions dlvr.it/T7ZBJM

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy | Science Advances science.org/doi/10.1126/sc…

Yesss!! It's out in Developmental Cell!🥳Check it out to see lots of new exciting data on the axonal ER and local translation compared to the pre-print. Thanks to the reviewers for their insights that helped improve this study. And many thanks to all involved, a real team effort!

Another Christophe Leterrier & Subhojit Roy joint out! What if the periodic axonal scaffold was formed by… liquid-liquid phase separation? Work by Nick Boyer, our terrymosoly et al. showing that spectrin repeats can drive droplet formation. These could travel to the distal axon…

Ribosome-Associated Vesicles promote activity-dependent local translation | bioRxiv biorxiv.org/content/10.110…

ER-associated biogenesis of PINK1 preprotein for neuronal mitophagy biorxiv.org/content/10.110…

Our new paper! mRNAs play structural roles in the cytoplasm. The longest mRNAs bound to FXR1 generate an mRNA-protein assembly that plays an essential role in cellular signaling by enabling proximity of proteins without RNA binding domains. cell.com/cell/fulltext/…

The big one is out 🎉 So over the moon to see our latest work with Steph Vassilopoulos published in Science Magazine. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: science.org/doi/10.1126/sc…