Our latest paper out today Circulation! New data on loss of nuclear envelope integrity, oxidative stress & subsequent DNA damage as key substrates in the molecular pathology of #ARVC. Great collaborative effort! Mario Delmar Alicia Lundby Marta Pérez-Hernández ahajournals.org/doi/abs/10.116…

Out now from the Mario Delmar lab. "Loss of nuclear envelope integrity and increased oxidant production cause DNA Damage in adult hearts deficient in PKP2: A molecular substrate of ARVC." ahajournals.org/doi/abs/10.116… Marta Pérez-Hernández Chantal van Opbergen Alicia Lundby

Researchers are studying pathways involved in arrhythmogenic right ventricular cardiomyopathy, which can lead to severe arrhythmias and progressive loss of heart muscle, to support future therapeutic targets: bit.ly/3bRbFA4 Circulation #CardioTwitter

#ICYMI: Nuclear envelope integrity and DNA damage in ARVC Mario Delmar Alicia Lundby Marta Pérez-Hernández Chantal van Opbergen NYU CVRC #AHAJournals

Congratulations to Chantal van Opbergen on winning the Arrhythmogenic Cardiomyopathy Basic Science Research Prize, at the International Symposium on Arrhythmogenic Cardiomyopathies in Zurich! Mario Delmar Marina Cerrone @alicialundby

Our paper on #exercise in #ARVC recognized as one of top 10 in #arrhythmias in #EHJ for 2022. Mario Delmar NYU CVRC NYU Grossman School of Medicine Chantal van Opbergen

Always wanted to learn more about the intercalated disc? 🫀Our very extensive review on the topic now online in preprint Physiological Reviews! Mario Delmar Morten Schak Nielsen NYU CVRC NYU Grossman School of Medicine journals.physiology.org/doi/abs/10.115…

Exciting times ahead for the #ARVC field! Great presentation by RocketPharma in Late-Breaking Oral Session @ASGCT about our preclinical studies on gene therapy for #PKP2ARVC. Stay tuned/Tune in on Sunday for the talk of Mario Delmar at #HRS2023 for more details.. Marina Cerrone

Congratulations to Chantal van Opbergen ,one of our oral presentation finalists. Amazing talk on gene therapy of arrhythmogenic cardiomyopathy!

Our preclinical study in collab with Rocket Pharmaceuticals on #genetherapy for #PKP2 #ARVC out now in preprint! The U.S. FDA IND application based on this study (+ extensive toxicology studies) recently received clearance to start Phase I clinical trials. 🧬🫀Marina Cerrone Mario Delmar

End of an era; Yesterday was my last day at NYU CVRC… The last 4 years were absolutely amazing and I’m so grateful for all the support and opportunities and I’ve gotten from Mario Delmar , Marina Cerrone and the rest of the team! Will miss NYC a lot! Next stop -> Amsterdam🇳🇱

Very excited to see our latest paper on #genetherapy for #PKP2 #ARVC published in Circulation: Genomic and Precision Medicine! 🫀🧬 Great collaboration with Rocket Pharmaceuticals! Marina Cerrone NYU CVRC NYU Grossman School of Medicine ahajournals.org/doi/10.1161/CI…

NYU Langone Health NYU CVRC

From Chantal van Opbergen Mario Delmar Marina Cerrone + team: AAV-Mediated Delivery of PKP2a Arrests Progression of ARVC in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans ahajournals.org/doi/abs/10.116… AHA Science #AHAjournals #CardioTwitter #Genetics 📽️H.J. Tadros

Exciting to be part of the Moderated Poster session at #FCVB2024 today, to tell everything about pro-arrhythmic mechanisms in the #PKP2 deficient atrial myocardium! 🫀#ARVC #AF #RYR2 Stay tuned! Mario Delmar Marina Cerrone Alicia Lundby NYU CVRC

Very proud and honored for this amazing recognition of our work on #genetherapy for #PKP2 #ARVC !! 🫀🧬 Special thanks to SADS Foundation for this nomination and the entire team for this phenomenal teamwork! Marina Cerrone Mario Delmar NYU CVRC NYU Grossman School of Medicine