How do functions of different neuronal subtypes change in neurodegeneration?

Sabine Krabbe is developing tools to uncover how local pathology impacts neuronal function in the amygdala & how aberrant activity triggers further pathological changes in interconnected regions

We built CZ #CellxGene to be a one-stop shop for curated #SingleCell RNAseq data, access + analysis.

At 85M+ cells & 1317 datasets, the platform is making it possible to train more sophisticated & accurate computational models bit.ly/3y4pMwM

Patient-led movements are critical to catalyze the search for treatments & cures for rare diseases. Watch how #RareAsOne grantee Brian Wallach’s fight against ALS led him to launch I AM ALS + revolutionize how we treat disease. Watch #ForLoveAndLife on @Primevideo

With over 3,000 citations, DeepLabCut 🦄 has become an indispensable open source tool in motion-tracking research. Its applications span from understanding neural circuits to wildlife conservation. Kudos to @trackingactions + Alexander Mathis! bit.ly/3USOV5t

Using the lung microbiome as a predictor of outcomes for children undergoing bone marrow transplants can improve outcomes, suggests new Nature Medicine study led by @MattZinter_MD of UCSF School of Medicine & #CZBiohubSF Pres Joe DeRisi.

Learn more ➡️
czbiohub.org/news/lung-micr…

Latin America & the Caribbean are home to >8% of the world’s population, yet Hispanic people + people of LatAm ancestry comprise only 1.3% of all genomics data.

Read how #SingleCell researchers are building relationships to diversify the Human Cell Atlas czi.co/3uV8H7k

We’re thrilled to announce #KempnerInstitute ’s first cohort of post-bac scholars! These 4 recent college grads will undertake extensive mentored research & coursework with 2 years of funding & professional development. Read more: bit.ly/3KhCJ9x @harvardGSAS #AI #NeuroAI

Imaging scientist Leonel Malacrida + team are making strides in deep tissue imaging with DIVER, novel tech that will revolutionize metabolic live imaging in cells + tissue using specialized detection & multiphoton excitation #ImagingTheFuture

With expertise in large-volume light-sheet imaging, high throughput screens & circuit-based tools, neuroscientist Li Ye wants to develop technologies for a whole-body approach to studying neurodegeneration #BrainAwarenessMonth

Stunning details of mitosis revealed by stimulated emission depletion (STED) microscopy.

Richard Cole works to image cells + tissue in their intact environment for longer periods of time, and is part of a collaborative team hosting an intercontinental imaging workshop

Commercial imaging systems are often too expensive for small institutions—leaving many without the tools to measure human biology in action.

Kevin Cash + Josh Brake are developing a solution that leverages the power of nanosensors

👋 Say hi to the Exploratory Cell Networks teams collaborating across institutions to develop #tech to deepen our understanding of the cell. This kick off meeting facilitated new connections + built momentum for their projects that are pushing the frontiers of cell science

Brain regions have specific mechanical signatures throughout aging and in pathology.

Diz-Muñoz Lab is working on the first biomechanome of the brain to understand the molecular players involved in the brain’s physiological & pathological mechanical properties

Findings in Nature Communications from the Storniolo + Nakshatri labs at @iumedschool shed light on ancestry-related differences in breast cancer susceptibility. Variations in disease outcomes are linked to populations of ZEB1-expressing stromal cells. bit.ly/3vSUmJ9

Say hello to the first group of Investigators at #CZBiohubNY ! Check out their projects to enable Biohub New York to harness the power of immune cells for early detection of cancer and neurodegenerative diseases.

Learn more ➡️
czbiohub.org/ny/

The first 7 #CZBiohubNY Investigators aim to build new tools to characterize + bioengineer immune cells that will eventually detect disease earlier bit.ly/4dDKunl

“Humans have a hard time visualizing something in 20,000 dimensional space, So we need the help of computers.”

In the newest episode of Moira Gunn, Stephen Quake spoke with Moira Gunn about how we’re using #AI to create predictive models of cells bit.ly/4acqpSn

Physics 🤝 Biology

#CZBiohubSF Investigator Hawa Thiam is designing new ways to experimentally replicate the physical forces cells encounter in the body bit.ly/3vbEIbo