All the science ladies 🎶🎵 tune in today at 4:30 Mskcc.org/sciencespotlig… to hear from these brilliant scientists hosted by Karuna Ganesh. Being able to launch this #WomenInSTEM endeavor has been the most gratifying part of 2020. Tune in next week for Prof. Akiko Iwasaki & Ashi_W!

👏 Congratulations to Cornelius Taabazuing (Cornelius Taabazuing) who was named to Cell Press' 100 inspiring Black scientists in America. Cornelius is a research fellow in the Bachovchin lab studying functions of enzymes in normal and pathological processes. crosstalk.cell.com/blog/100-more-…

Just posted Daniel Ball’s latest work. He’s presenting a poster on these findings at #emboinflammasomes this week - check it out! Oxidized thioredoxin-1 restrains the NLRP1 inflammasome biorxiv.org/content/10.110…

Our latest preprint establishes new insight into NLRP1 inflammasome activation with the discovery that a cellular oxidoreductase, thioredoxin-1, binds NLRP1's NACHT-LRR domains and affects its activity. Check out the link below biorxiv.org/content/10.110…

Many thanks to Dan Bachovchin, all authors, and all Bachovchin lab members.

Daniel Ball Congrats Dan! I'm super excited to see all of implications of this new sensing role in cellular homeostasis!

And yes, we have a flag .... 🤓 #EMBOinflammasomes

Check out our latest on the NLRP1 inflammasome. Here, we show NLRP1 activity is restricted by its interaction with the cellular redox protein TRX1. Huge congrats and appreciation to all authors. Very grateful to Dan Bachovchin for mentorship and support. science.org/doi/10.1126/sc…

Our latest work led by Daniel Ball shows that oxidized, but not reduced, TRX1 binds to and represses the NLRP1 inflammasome, revealing that the innate immune system senses reductive stress. science.org/doi/10.1126/sc…

What danger signal does NLRP1 sense? Daniel Ball Dan Bachovchin show in Science Immunology that oxidized thioredoxin (TRX1) stabilizes NLRP1 under homeostatic conditions. Onset of reductive stress dislodges TRX1 causing #inflammasome activation @MSKCancerCent 📖➡️bit.ly/NLRP1sensing

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So excited that we finally have the ACTIVE NLRP3 inflammasome structure, thanks to super talented Le Xiao Le Xiao, and Venkat Magupalli Venkat Giri Magupalli! nature.com/articles/s4158…

Negotiating a faculty position can be confusing. Here, as a group of new faculty members, we pull back the curtains to explain nuances, identify negotiable components, and build a framework for the process of negotiation based on our recent experiences. authors.elsevier.com/a/1gDYR3S6GfIy…

Beyond excited to share the first preprint from my lab!! We identified IL-18 and IL-1Beta as direct substrates of the noncanonical inflammasomes and uncover the molecular basis of IL-1Beta recognition and processing. #happyNewPI. biorxiv.org/content/10.110…

Totally wild. The functional linkage of the CARD module to host defense via cell death is an evolutionarily ancient property 🤯 CARD-like domains mediate anti-phage defense in bacterial gasdermin systems | bioRxiv biorxiv.org/content/10.110…

Must watch “The kindest person in the room is often the smartest”

Most deserving young investigator I know! Congrats.

nature.com/articles/s4158… While otherwise quite exciting, it's a bit surprising to think that these folks rediscovered Trx binding and its functional importance 2 years since it was disclosed on biorxiv...

Our latest work by michael geeson and Jeffrey C. Hsiao shows that NLRP1 associates with TRX1 using a transient disulfide bond. Their discovery showcases the predictive power of AlphaFold-Multimer! biorxiv.org/content/10.110…

Wonderful advancement in our understanding of the molecular mechanisms that enable oxidized TRX1 to interact with and modulate NLRP1. Kudos to michael geeson, Jeffrey C. Hsiao, and Lydia Tsamouri on this great work! biorxiv.org/content/10.110…