Out now in ChemComm "Visible light-mediated difluoromethylation/cyclization in batch and flow: scalable synthesis of CHF2-containing benzimidazo- and indolo[2,1-a]isoquinolin-6(5H)-ones" by Sandip Murarka, Arseniyadis, & co! Chemistry_QMUL Read it here 👇 buff.ly/4dfQlyf

The IRT2024 symposium in Tokyo has just started

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40 - Tong - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/bp…

It was another great day at IRT2024 IS3NA in Tokyo and it was my great pleasure to present our APOBEC3A inhibitors. Huge thanks to collaborators and funders and Massey University SynGenis Pty Ltd for travel support!

Inspiring rewriting of cononical and non-canonical nucleic acid stability rules full of beautiful front cover images from Naoki Sugimoto of Konan FIBER🧬甲南大学先端生命工学研究所 brings welcome start to day 3 of IRT2024.

The Ikehara award at the IRT2024 for Naoki Sugimoto. Congratulations!

Our group's research has been published in NAR, demonstrating that 2'-formamide-modified nucleic acids can reduce the off-target effect of siRNA while maintaining its on-target effect. This work is attributed to Dr. Nomura and Dr. An. Congratulations! academic.oup.com/nar/advance-ar…

Freezing Functional Nucleic Acids: From Molecular Reactions to Surface Immobilization (B. Liu et al.) onlinelibrary.wiley.com/doi/10.1002/cb…

DNA Hierarchical Superstructures from Micellar Units: Stiff Hydrogels and Anisotropic Nanofibers (Quentin Laurent, Hanadi F. Sleiman Hanadi Sleiman and co-workers @McGillChem) #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…

Great talk by Sara N. Richter at the IRT Tokyo!

Jory Lietard Research Group on stage at IRT2024 Japan talking about RNA microarrays. Great collaboration between Austria and France ANR Debart Françoise ChemBioNAC IBMM - Institut des Biomolécules Max Mousseron CNRS Chimie Université de Montpellier University of Vienna STEM

Teams NuEP Team and ChemBioNAC from IBMM - Institut des Biomolécules Max Mousseron well represented at #IRT2024 in Tokyo 🇯🇵 🤩with #Suzanne_Peyrottes Béatrice Roy Vasseur Jean-Jacques Debart Françoise and #François_Morvan Université de Montpellier CNRS 🌍 #nucleotides #oligonucleotides

At IRT2024 Tokyo 3 awardees by IS3NA and JSNAC for their outstanding contributions in Nucleic Acids field Peter Nielsen, University of Copenhague Eiko Ohtsuka, AIST Naoki Sugimoto, Konan University

More exciting work from Jacek Jemielity and Joanna Kowalska: 5'-phosphorothiolate cap analogues can be MORE efficient than their natural congeners... Trinucleotide cap analogs with triphosphate chain modifications doi.org/10.1093/nar/gk…

Super happy that our ligase-based method to produce modified DNA was published today Nature Communications Congrats to all, especially Nazarii SABAT 🇺🇦 ! Thanks to Roche and PEPR MolecularXiv for funding! INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie doi.org/10.1038/s41467…

Impressive work. Congratulations Hollenstein group, Nazarii SABAT 🇺🇦 and the team!

Evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole to triphosphate activation | PNAS pnas.org/doi/10.1073/pn… Part 3 of the RNA assembly Trilogy. 1/7

Interesting talk from Guillaume (aka Clavé Guillaume, PhD) from ChemBioNAC today Chemistry_QMUL Thanks to CNRS Chimie for providing this opportunity to Guillaume with a travel grant #oligonucleotides, #sulfoclick, #bioorthogonal, #DNA, #RNA

Recent findings from the Jack Szostak lab reveal how ancient RNA enzymes transitioned from simple phosphorimidazole substrates to more complex triphosphate substrates. This evolution highlights the adaptability and flexibility of early life forms, providing insights into the