DECODING GENOMES - from sequences to phylodynamics: We are proud to present our book on how to analyse genomic sequences with an evolutionary perspective. See decodinggenomes.org for a free pdf, Amazon links for print orders, and further information. Great team effort 1/2

So its out Genome Biology: genomebiology.biomedcentral.com/articles/10.11…. All you need to know about DNA methylation in annelids🪱! This has been a great collaboration with the Martín-Durán lab lab, led by kero guynes. One of the main findings is that the methylome erodes throughout development and beyond! 1/

Very pleased to welcome our new stem mollusc Shishania aculeata published today in Science Magazine! A great collaboration led by Guangxu Zhang who discovered these amazing fossils with Xiaoya Ma and Jakob Vinther. science.org/doi/10.1126/sc…

Excited to share our work on animal genome structure led by Tom Lewin! We assembled a dataset of 64 animal genomes and quantified shuffling rates to provide a comprehensive view of genome evolution across various lineages. 1/3 doi.org/10.1101/2024.0…

We have a 3 year University postdoc position for a bioinformatician open in my group. Deadline for application is 30 August. More details here: jobs.univie.ac.at/job/University… Please apply or retweet.

Passionate about AI + Proteins? We are hiring deep-learning scientists at all levels. We are in a privileged location with extensive resources. Junior or senior, if this resonates with you, apply now! recruitment.crg.eu/content/jobs/p…

We are looking for a computational PhD student to take lineage tracing in human to the next level. Read our preprint biorxiv.org/content/10.110… and the job ad recruitment.crg.eu/content/jobs/p…

Our short report on a remarkable feature of #ctenophores out now: Reverse development in the ctenophore Mnemiopsis. We show that Mnemiopsis is capable of reversal from mature lobate to early cydippid🤩. Michael Sars Centre Universitetet i Bergen bioRxiv #rejuvenation biorxiv.org/content/10.110…

Happy to announce our paper about the GTRpmix model and exchangeability matrices designed for use with profile mixture models for eukaryote and eukaryote+archaea data sets is published: academic.oup.com/mbe/advance-ar…

What if you could deliver molecular tools directly into oocytes without microinjection? In our new paper, online today Development (doi.org/10.1242/dev.20…), we introduce VitelloTag, a new cargo delivery tool to enable injection-free genome editing. 👇Read on for a short 🧵

check out the CREsted package if you like to model & decode genomic enhancers or design synthetic enhancers

New WormBook.org chapter! With Nuria Flames Lab and Richard Poole we wrote Neurogenesis in C. elegans, now in Genetics: doi.org/10.1093/geneti… We discuss neuron development specifically, but do have a look if you think about acquisition of cell identity more generally

Major effort from the lab (💪Robert Frömel), finally on biorxiv: We built 60,000 fully synthetic enhancers and measured their cell state specific activity during blood stem cell differentiation. Why did we do that and what did we learn🧵? biorxiv.org/content/10.110…

Presenting our new bioRxiv: we combine single cell expression and chromatin accessibility data with gene perturbations to model Gene – “Regulatory”?* – Networks, in whole adult planarians X-plainer! 🧵👇 biorxiv.org/content/10.110… *the question mark will be resolved at the end

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (Marco Pregnolato), Schübeler Lab, and FMI science: cell.com/molecular-cell…

Happy to see this online, our new review/bioinformatic investigation on the origin and evolution of microvilli: onlinelibrary.wiley.com/doi/10.1111/bo… - also our first (but not last) collaboration with Gautam Dey's lab!

Thrilled to announce that I’ve been awarded an #ERCStG by the European Research Council (ERC)! We aim to uncover the timing and mechanisms of mammalian male germline mutation, as well as explore how primates lower their somatic mutation rates. The lab will be hiring soon—stay tuned!

Our new study led by brilliant PhD student Kelsey Williamson (along with many wonderful collaborators), resolves the root of the Eukaryote Tree of Life 🌍🧬 with unmatched precision! biorxiv.org/content/10.110…

Consider starting a new research lab at vib.ai to solve big questions in life sciences using AI

Our latest research on position-dependent transcriptional regulatory sequences in plants is now published! 🌿 More details in our preprint tweet and in this thread! 👇 nature.com/articles/s4158… 📄🔍 (1/5)