Join me at the Latsis Symposium on Genome Engineering #Zurich #switzerland June 13-14! Register now at latsis-genome-editing.ethz.ch/registration.h… Treutlein lab Ben Kleinstiver Raffaella Di Micco Sek Kathiresan MD Janice Chen Charles Gersbach Cejka Lab Teresa Davoli Jolanda van Leeuwen Cereseto Lab Anna Obenauf Prisca Liberali

Reviewer reviewing for CNS: "Needs 5 more cell lines, a new mouse model and 15 ChIP-Seq exps (+/- mutants)." Same Reviewer reviewing same manuscript for society journal "manuscript is well written and exps well designed, I have no further concerns". #AcademicGateKeeping

How the immune system holds the key to ageing. Today in nature by Alison Abbott nature.com/articles/d4158… we

For the last 2 years, I have been signing my name onto manuscript reviews. Its fair that authors know who is critiquing their papers, and it helps keep myself accountable to being unreasonable with demands. I also secretly hope authors feel they can reach out to talk as well.

Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag go.nature.com/44DO2Cc

What is the origin of our body? Our paper Cell shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta. cell.com/cell/fulltext/…

Join us! This is an exciting Ph.D project on #telomeres and #immunity with the opportunity to work with an outstanding group of leaders in #academia and #biotechs. Apply here 👇

An innovative doctoral research training network, focused on understanding the transition from robust health to frailty, is being launched by Uni of Birmingham, funded by Marie Skłodowska-Curie Actions Marie Skłodowska-Curie Actions, led by Prof Claudio Mauro, Inflammation and Ageing. birmingham.ac.uk/news/2024/sign…

DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies ow.ly/Q1Ba50RTI3e #lymphoidneoplasia #myeloidneoplasia #reviewarticles

Followed by the brilliant Raffaella Di Micco on senescence and immunity in blood cancer 🤩so cool

Back after a fantastic @embo meeting on cancer #evolution! 3 days learning about #tumor heterogeneity, #plasticity,#TME, therapy #resistance...spritz, piadina and friends (old and new!) made this meeting memorable! Thank yo Anna Obenauf Leila Akkari Giovanni Ciriello Luca Magnani!!

Now Online SenNet recommendations for detecting senescent cells in different tissues dlvr.it/T7n0tV

Interested in doing a PhD with me in experimental pragmatics/neuropragmatics, metaphor studies or language in vulnerable groups (psychosis and children with traumatic background)? Check this call (6 positions open!) and join us at #NEPLab IUSS PAVIA ➡️iusspavia.it/en/education/d…

To correct the market failures around pediatric #celltherapies and #genetherapies, Crystal Mackall & colleagues propose a new model to lead late-stage development and commercialize these outside of traditional routes in the US. Mackall Lab Stanford Medicine nature.com/articles/s4159…

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

There are many anti-aging companies into senolytics, with the goal of eliminating the senescent cells from the body. It turns out that it's a lot more complicated than that. Science Magazine by João Pedro de Magalhães science.org/doi/10.1126/sc…

Excited to share: Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging: Cell Stem Cell cell.com/cell-stem-cell… Huge privilege to work colleagues in the lab and with Andy, Stephanie and John

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Congrats Julia Magdalena Majewska Amit Agrawal . Thanks uri alon for great collaboration.

This is a great review in Cell Press on how to detect and assess cell senescence in vivo with great contributions from many colleagues: “Guidelines for Minimal Information on Cellular Senescence Experimentation in vivo” sciencedirect.com/science/articl…