New review to read: DOI: 10.1146/annurev-biochem-052621-092014

HMS news made an awesome video summarizing our recent work. if you’re a visual learner definitely check it out! vimeo.com/939142198

Habemus poster, distributor/Sales Agent La Distributrice and premier mundial FICUNAM.

Research reveals how mitochondria and the cell nucleus coordinate to create proteins

Hi there! Our review on “Mechanotransduction in stem cells” is finally published. With Carsten Schulte we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

I love this video describing our work led by Erik McShane! Thanks to everyone who helped put it together. cell.com/molecular-cell…

I’m thrilled to share that I will be starting as an Assistant Professor in Biochemistry & Cell Biology—BUMC this July! The Isaac Lab will be using genomics and biochemistry to investigate mitochondrial (and organellar) genome regulation. Recruiting at all levels!

Fantastic news! Could not recommend more for incoming students or anyone interested in doing a postdoc in mitobiology using really cool techniques!

Looking forward for some days of mtDNA and mitochondria science. Glad to have the opportunity to share our work in mtDNA quality control!

So excited to see this review out 🤩 Had a lot of fun reviewing the field with Karine Choquet Autum Baxter-Koenigs Stirling Churchman. It’s been fascinating to see how far the field’s quantitative understanding of splicing kinetics has advanced in just the last few years 🧫🔬

If you’re interested in what the last few years have taught us about the process of splicing, check out our latest review!Congratulations to my co-authors Hope Eliana Merens Karine Choquet Autum Baxter-Koenigs

Check out the latest review issue in Human Molecular Genetics focused on all things mitochondria! Great to work with ShuttLab and our trainees to provide an update on mtDNA in innate immunity.

Happy to see this review out! We focus on mitochondrial central dogma rates, highlighting the striking differences in gene expression rates between mitochondrial and nuclear genes, and synthesize a coherent model of mitochondrial gene expression kinetics.

Thank you to everyone that joined last week's EMBO meeting on mitochondrial gene maintenance and expression - for sharing your data and for all of the great discussions. We hope you enjoyed it as much as we did!

Preprint updated. The latest method for mitochondrial ribosome profiling. biorxiv.org/content/10.110…

Central dogma rates in human mitochondria (REVIEW) doi.org/10.1093/hmg/dd…

So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

🎉Our paper quantifying how RNA flows across subcellular compartments is published! 🎉 Read more in the preprint thread ⬇️ The paper contains an improved analysis of RNA flow rates and new collaborative work on DDX3X with Stephen Floor authors.elsevier.com/a/1jMoV3vVUPRm… Molecular Cell

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle authors.elsevier.com/c/1jMoV3vVUPRm… Published Molecular Cell Big thanks to fellow co-first authors Brendan Smalec Albert Xu Stephen Floor mentor Stirling Churchman +team!

I strongly recommend this opportunity! A once in a lifetime opportunity to work with a wonderful mentor on very exciting science.