And read the Research Briefing on this paper, here: nature.com/articles/s4159…

Explore the latest advances in electron microscopy instrumentation and methods that have greatly spurred progress in the physical and life sciences. Organized by
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New from Samuel A Myers! Combining genome-wide CRISPR–Cas9-mediated base editors with temporally resolved phosphoproteomics enables the functional screening of thousands of post-translational modification sites involved in T cell activation.nature.com/articles/s4159…

ESI-cryoPrep employs electrospray ionization to deposit charged macromolecule-containing droplets on EM grids. Researchers from Tsinghua University show the approach addresses challenges related to protein denaturation and preferred orientation. nature.com/articles/s4159…

Out today from the Jungmann Lab! A method for measuring labeling efficiency for improved quantitative assessment of protein organization at the single-molecule level. nature.com/articles/s4159…

Our latest Creature Column introduces the placozoan Trichoplax as a model for studying epithelial evolution, diversification and specialization.

nature.com/articles/s4159…

Research Highlight by Rita Strack: NeuralPlexer is a deep learning generative model for protein-ligand complex structure prediction.

Original paper: nature.com/articles/s4225…

Highlight: nature.com/articles/s4159…