DNA methylation-based predictors of health: applications and statistical considerations go.nature.com/34RklTE #Review by Paul Yousefi, @mathsuderman, Ryan Langdon, Oliver Whitehurst, george davey smith & caroline relton @MRC_IEU ICEP Bristol Population Health Science Institute

The splicing mechanism and the spliceosome #Figure from our recent #Review by Malgorzata Rogalska, Claudia Vivori & Juan Valcárcel on the regulation of splicing go.nature.com/3BDfNO4 Centre for Genomic Regulation (CRG) UPF Barcelona The Crick

In this Review, the authors summarize recent progress in elucidating the highly conserved processes of macroautophagy and microautophagy, the pathological relevance of autophagy-related genes in Mendelian and complex diseases, and the evolution of the autophagy pathway

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution | Nature Reviews Genetics nature.com/articles/s4157…

Our featured article: Prime editing for precise and highly versatile genome manipulation go.nature.com/3zUB9Wc #Review by Peter Chen & David R. Liu Free to read here: rdcu.be/cZaEn

Best practices for single-cell analysis across modalities go.nature.com/3K1Y3Pv #ExpertRecommendation

DNA methylation research has matured from a phase of discovery and genomic characterization to one seeking deeper functional understanding of how this modification contributes to development, ageing and disease

In this new Review, now live online, Jan Budczies, Albrecht Stenzinger and co-authors discuss the clinical utility, challenges and emerging improvements of tumour mutational burden as a predictive biomarker for immunotherapy: nature.com/articles/s4157…

Merly Vogt recalls a seminal 2011 paper by Eric Greer Lab et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation

Calling all students to take part in the 1st Springer Nature Berlin Slam! Are you passionate about your research and want to talk about it in front of a live audience during Berlin Science Week? Get in touch and become one of our Slammers! More info: go.nature.com/SNBerlinSlam20….

Progress in toxicogenomics to protect human health go.nature.com/4cMYREl #Review by Matthew J. Meier Health Canada and PHAC, Joshua Harrill U.S. EPA, Kamin Johnson Corteva Agriscience, Russell S. Thomas U.S. EPA, Weida Tong U.S. FDA, Julia Rager UNC Institute for Environmental Health Solutions UNC School of Medicine UNC Public Health & Dr. Carole Yauk Université d'Ottawa | University of Ottawa

Hope you enjoy our review on toxicogenomics! It’s the silver anniversary of our field! The term was coined 25 years ago by Nuwaysir et al. and the field has matured into a staple of modern toxicology. Huge thanks to the incredible team that helped put this together!

Interested in chromosomes, genetic syndromes and cancer? Check out our new review on Aneuploidy syndromes by Carolina Villarroya & Marcos Malumbres in Nature Reviews Genetics Vall d’Hebron Institute of Oncology (VHIO) CNIO Stop Cancer ICREA Community nature.com/articles/s4157…

Check out our new review in Nature Reviews Genetics about aneuploidy syndromes, cancer and ageing Malumbres Lab Marcos Malumbres CNIO Stop Cancer