2-stage network Mendelian randomization study suggests: coagulation FXI, a druggable target, is important mediator of associations of obesity, 🚬smoking, & insomnia with venous #thrombosis #VTE risk. World Thrombosis Day Shuai Yuan Susanna Larsson Karolinska Institutet jthjournal.org/article/S1538-…

Editorial from ⁦⁦Michael Makris⁩ Yazan Abou-Ismail, MD - د. يزن أبواسماعيل⁩ on AI the future of scientific communication. "However, AI will likely soon be used to screen all manuscripts for aspects such as appropriate length, structure, language, and citation accuracy” rpthjournal.org/article/S2475-…

A meta-analysis on #Thromboembolic events in severe postpartum hemorrhage treated with recombinant activated factor VII. Thromboembolic events was 0.72% vs 1.82% in women not treated and treated with recombinant activated FVII, respectively. RPTH rpthjournal.org/article/S2475-…

Von Willebrand factor in #inflammation and heart failure: beyond thromboembolic and bleeding risk EHJ Editor-in-Chief #VWF #HeartFailure academic.oup.com/eurheartj/adva…

The final version of our manuscript is out. Global prevalence of hereditary thrombotic thrombocytopenic purpura determined by genetic analysis. We estimated a global prevalence of 23 cases/million vs 1/million of previous studies ⁦Blood Advances⁩ ashpublications.org/bloodadvances/…

Lack of #FVIII detection in humans/dogs with an intron-22 inversion challenges hypothesis regarding inhibitor risk It argues against promotion of immune tolerance through expression of partial FVIII proteins in intron-22 inversion patients JTH⁩ jthjournal.org/article/S1538-…

Interesting study assessed a broad panel of #cardiovascular biomarkers and risk factors for the prediction of major adverse cardiovascular events and cardiovascular death in 2192 #cancer patients. jthjournal.org/article/S1538-… JTH

Another study on AVWS during extracorporeal membrane oxygenation support (ECMO). Results suggested that almost all ECMO patients develop partial or complete loss of #VWF HMWM within a few hours after device implantation JTH⁩ jthjournal.org/article/S1538-…

An elegant review on gynecological bleeding symptoms and their management in women with moderate and severe von Willebrand disease. Control of HMB often requires a combination therapy. #VWD Haemophilia Journal onlinelibrary.wiley.com/doi/10.1111/ha…

Where have all the congenital TTP cases gone? Paper in Blood Advances suggests we only know of a fraction of cases we should expect. Do the die early in utero, stillbirths, undiagnosed and alive? tinyurl.com/4ssnda5b

Thank you for highlighting our study Michael Makris We hope that our results raise the attention of suspecting hTTP in cases with microangiopathic hemolysis and thrombocytopenia.

📣NEW ISTH Pulse Podcast Episode: From paper📝 to passion❤️‍🔥, enjoy hearing Omid Seidizadeh explain how he began his career in von Willebrand factor research with Geoff Barnes as our host! Click here to listen and subscribe: bit.ly/3ZcKiqK

Thrilled to be the first guest on the International Society on Thrombosis and Haemostasis (ISTH) Pulse podcast! Huge thanks to the ISTH and Dr. Geoffrey Barnes Geoff Barnes for the outstanding hosting. Proud to be an ISTH member and excited for future episodes!

Check out this new podcast series from ISTH to meet early career professionals shaping the future of thrombosis and hemostasis! New episodes dropping each month.

On our latest ISTH Pulse podcast episode, you can hear Omid Seidizadeh trace his journey to von Willebrand factor research. Click here to listen and subscribe: bit.ly/3ZcKiqK

A comprehensive review of the wide application of Endothelial Colony Forming Cells to understand the pathophysiology of von Willebrand disease and rare bleeding disorders. #VWD JTH Ruben Bierings jthjournal.org/article/S1538-…

A major step forward in understanding fibrinogen regulation using Whole-genome data at population scale. 18 loci were newly found. In total, 54 regions are found to be associated with #fibrinogen. Blood Journal ashpublications.org/blood/article-…

#Global prevalence of hereditary thrombotic thrombocytopenic purpura determined by genetic analysis. This data reveals the importance of an accurate diagnosis of #congenital #TTP and an urgent need to solve the underestimated diagnosed cases of TTP ashpublications.org/bloodadvances/…

Interesting data, from four French hemophilia A treatment centers, proposes indications for #DDAVP use in patients with #hemophilia based on F8 gene variants for minor and major invasive procedures. Thrombosis & Haemostasis, TH,TH Open Peter Lenting thieme-connect.com/products/ejour…

Between 800,000 and 900,000 years ago, the population of human ancestors crashed, a 2023 Science study finds. The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. scim.ag/8hk #ScienceMagArchives