📢Publication alert! In a proof-of-principle study in 15 #APS patients, we showed that altering the gut microbiome with vancomycin affects biochemical disease activity after 7 days. I think this opens new avenues for human APS research thieme-connect.com/products/ejour…

There is no specific treatment for factor V Leiden. It is very common in European populations. It is found in 5% of the UK population. Although it increases the risk of venous thrombosis, the management once a person has had a thrombosis, is the same irrespective of the presence

The reality of gene therapy in #hemophilia A. This will be less impactful than generally assumed, at least for now. The widespread use of emicizumab and the durability issues with Roctavian are having a big impact in the decision on whether to go for gene therapy in hemophilia A

I agree. I believe most persons under the age of 40 with severe #hemophilia alive today will have gene therapy in their lifetime. Widespread use of gene therapy may not happen for another 20-30 years, but it will happen. Hemophilia is a monogenic disease and is the perfect target

The OCEANIC-AF randomized trial of the factor XIa inhibitor asundexian was stopped early owing to a higher incidence of stroke or systemic embolism than with apixaban therapy among patients with atrial fibrillation. Full trial results: nej.md/473TRdc #ESCardio

Aspirin monotherapy compared to clopidogrel monotherapy was associated with similar cardiovascular and bleeding outcomes at 1 year after PCI with DES. Read the 1-year follow up STOPDAPT-3 Trial in #EHJ. doi.org/10.1093/eurhea… #ESCCongress #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

Interesting book about how stigma, class and discrimination have had enormous impact on COVID-19 and HIV infection/death. Although largely exploring the US situation, there is a fascinating chapter on parallels with Greece during the worse period of austerity. The author is a

Where have all the congenital TTP cases gone? Paper in Blood Advances suggests we only know of a fraction of cases we should expect. Do the die early in utero, stillbirths, undiagnosed and alive? tinyurl.com/4ssnda5b

What happens when a virologist develops recurrence of her breast cancer? She injects two viruses into the tumour to shrink it. This is either crazy or genius and I can not decide which. Apparently self experimentation does not require ethics review! tinyurl.com/2phe4cc4

The 2024 UK guidance paper on the measurement of anticoagulant levels has been published in British Journal of Haematology. tinyurl.com/52hks7sj #anticoagulant #heparin #LMWH

Rituximab refractory or intolerant immune TTP cases are very difficult to manage. Paper in British Journal of Haematology from France suggest that Daratumumab is a reasonable therapeutic option. tinyurl.com/59p7ybwt #TTP #daratumumab

The Tour of Brittain passed through the bottom of our road this morning. This has to be one of the shortest spectator events; it was over in 2-3 seconds. (Actually they have not started racing yet - they do this when they reach the hills in a few minutes). #Sheffield

Amazing chest x-ray of a man with 2 months history of shortness of breath in NEJM. Physical examination was unremarkable! No wonder we go for imaging so often these days. Findings are due to metastatic tumour. tinyurl.com/y58xk6hb

Looking forward to the meeting tomorrow. This was last years venue. Tomorrow I am told the venue is even more special.

Great dinner last night with the Catalan Haemophilia Association, ⁦Brian O Mahony⁩ and the ex-mayor of Barcelona Dr Xavier Trias. Both Brian and I loved our unique presents. #hemophilia

Arrived at the meeting of the Catalan Haemophilia Association with ⁦Brian O Mahony⁩ where we are both speaking. Meeting is at La Pedrera, Gaudi’s last house and now a World Heritage Site.

Recommendation (in Catalan) for Haemophilia carriers at advanced age. This was a project by the Catalan Haemophilia Association.

The wonderful Cor Noctes choir performed at the Catalan Haemophilia Association meeting in Barcelona. The choir was found by a member of the association with #hemophilia who died suddenly at an incredibly young age.

Interesting snippet of information at the Biomarin investors day (I am not an investor). They are developing a novel subcutaneous treatment for von Willebrand disease. I believe I know which one it is, but until confirmed I can not say anything more. Work so far has been by an

Exactly as I thought! Not many academic groups have been developing nanobodies as potential treatements for von Willebrand disease. I will ask them if the collaboration has been made public yet. They actually follow me on Twitter and they may wish to confirm the collaboration.