Epigenetic aging clocks have become a commonly used metric in medical research and are being marketed to consumers. The new Ground Truths with Prof Steve Horvath, who discovered these clocks a decade ago, provides a frank appraisal of their progress, limitations, and promise. With

Rapamycin PEARL Study Results: We detected dose-dependent (10 mg group) and sex-specific improvements in lean tissue mass, pain, social functioning, overall QoL, and overall osteoarthritis score in females, and in bone mineral content in men. medrxiv.org/content/10.110…

Rapamycin News Not to mention our rapamycin "super-responders" and associations with improved gut health and lipid metabolism You're not going to want to miss our webinar on tuesday the 27th

Been saying for a while cancer is not as easily modifiable as is CVD. Avoiding CVD is almost trivial now. What we need are cancer breakthroughs. It is of note here that many anti-aging drugs are strongly protective from cancer e.g. rapamycin, trametinib and Nrf2 activators.

Nice breakdown on why prescription drugs are so much more expensive in the US …

The 11th Annual ARDD Meeting is underway. This fully booked event sees the Academy joining as a Tier 3 sponsor. In the next five days, 180+ experts will discuss advancements in pharma & biotech, focusing on metabolism, neurodegeneration, muscle wasting, & aging-related disease.

[San Francisco] A pretty big Vitalist Longevity meetup happening tomorrow (Tuesday AUG 26 @ 5:30pm) — come out and meet some new people! RSVP: lu.ma/z95szina

More great news! Now 50% of the first subproject is funded when it comes to conduct the largest lifespan analysis of 568 mTOR inhibitors that has ever been done. The purpose with this project is to uncover even more potent mTOR inhibitors than Rapamycin when it comes to extending

Rapamycin News ThruTheFog And our rapamycin bioavailability manuscript suggests no significant differences in bioavailability (for generic or compounded rapamycin) between men and women -- unlike mice and marmosets

Wow, the 2024 cohort in the ITP is fire. GlyNAC, trametinib Rapa, mianserin, anti histamine, deprenyl, sildenafil, apelisib. Two combos, obscure kinase inhibitors, the best pre rapa drug (deprenyl), several repurposing allstars. It has everything! nia.nih.gov/research/dab/i…

How to increase your odds of becoming a ‘SuperAger’ fortune.com/well/article/h…

mTOR and SGLT-2 Inhibitors: Their Synergistic Effect on Age-Related Processes mdpi.com/1422-0067/25/1…

Super exciting: the safe, repeat-dosable, good-delivery-not-just-to-liver gene therapy platform of Entos (& underlying Oisin Bio) now published & in high profile journal. This platform will do great things. And aging applications already in development. cell.com/cell/fulltext/…

atrocity of aging: 16 courts, 100s of people, lots of fun, not a single person over 70. Do you think they don't want to play and have fun? They can't, aging robbed them of their abilities. its an attrocity and its very sad... its coming for all of us, in very short order

An interaction I have almost every week: "Did you see X intervention increases lifespan by (decent) % ??" "does it pass the Matt Kaeberlein test?" "what's that?" The most important tweet in longevity, and one I reference *every single week.* A 🧵:

First look at the genome sequence of Greenland shark to find possible clues that could explain their mind-boggling extreme lifespan of up to 400 years. - 70% of the genome is repetitive elements - many uniquely duplicated genes, many related to DNA repair pathway - p53 is not

🧵 1/8 🎉 Our latest collaborative publication, "Challenges and recommendations for the translation of biomarkers of aging", has just been released in Nature Aging (Nature Aging). Biomarkers of aging predict biological age and its response to interventions but face challenges in

🚨 Applications for the Time Fellowship Cohort 2 are OPEN! 🚨 Apply Today!

Short report: The state of the mitochondria portion of the aging biotech field: 50 companies! $1.4+B raised 700+ people 150+ clinical trials many MoAs/targets: mitophagy, transplant, fission, NAD+, UrolithinA, CD38, PINK1, PPARδ, DRP1, USP30, Complex 1, OMA1, & more Read on:

Learn the latest in Reproductive #Longevity over a cocktail 🍸 October 15th we have a star-studded panel with the leaders in Reproductive Longevity: Jennifer Garrison Bérénice A. Benayoun, PhD and OB/GYN Dr. Lizellen La Follete 🤩 🔗lu.ma/knbzgkim 5/11