X-chromosome inactivation (XCI) A subject collection from Development marking 60 years since Mary Lyon proposed the theory of XCI in 1961. 🪢 Read a series of review-type articles related to this topic: journals.biologists.com/dev/collection…

Calling all authors in Biology of Sex Differences! If you are with 6 years of degree completion you are eligible for an early career award. You get $$ and a speaking slot at #OSSD25. OSSD Deadline is Sept 1.

Our newest pub📢: Menopausal hormone therapy (MHT) can be beneficial or not on brain health. Why? 1) length of time since menopause (too late=not as effective); 2) type of estrogens used (E1 not as effective as E2) ++. Here we 👀E1 vs E2 on neuroplasticity onlinelibrary.wiley.com/doi/10.1002/hi…

Coming to #ECI2024? Join us for an early run on Tuesday 3rd Sept, 6.30am. This 5km run will be raising funds for Breakthrough Cancer Research as one of the social events of ECI2024. 🏃🏃‍♂️🏃‍♀️ Registration and donations: breakthroughcancerresearch.ie/eci-5km-in-dub…

Fascinating talk on sex differences in type I IFN responses for the regulation of antiviral immunity by Prof. Marcus Altfeld. I much appreciated the thoughtful inclusion of transgender individuals and detangling of genetic and hormonal influences #eci2024 EFIS yEFIS

Very exciting work from Petter Brodin published today in @nature!

Immunological studies in trans-individuals undergoing gender affirming hormone therapy dlvr.it/TCqNXv

Nature research paper: Immune system adaptation during gender-affirming testosterone treatment go.nature.com/4g9lyWh

This incredible paper by Petter Brodin is what the field has been waiting for! It's shocking the extent to which testosterone regulates the components of the immune system which are dysregulated in the infection-associated chronic illnesses! Type I IFN responses ⬇️ NK function ⬆️

What causes differences in biological sex? In our latest preprint, Angela Jones takes our lab in a new direction, revealing mechanisms of sex-biased gene expression and identifying abundant sex-biased eQTL throughout the genome (1/6) medrxiv.org/cgi/content/sh…

Super excited to see my first preprint from grad school come out! Check out the 🧵 for some new discoveries in how biological sex impacts the transcriptome 🧬

Warm thanks to prof. Margaret McCarthy @UM_MIND for this lovely News & Views paper nature.com/articles/d4158… in relation to our recent work on Immune adaptation during gender-affirming hormone therapy: rdcu.be/dS8VI

Excited to share our new paper on temporal analysis of vaccine+/- adjuvant hours to 100 days (14 time pts). Vax alone induces new baseline immune state early & persists to 100 days, and that state predicts vax responses in an indep cohort. cell.com/cell-reports/f….

Check out this exciting story from Dennis Ko & Angela Jones using the innovative scHi-HOST system to reveal cell-intrinsic mechanisms of sex-biased gene expression. It's been fun thinking about this project together and I'm looking forward to what's next from this team!

Aging-driven and sex-dependent molecular changes in skin fibroblasts drive the emergence of invasive and therapy-resistant melanomas in male mice Cell Ashi_W lacroix🅿️a🅿️i cell.com/cell/fulltext/…

Happy to share my co-1st author paper in nature on how the immune system adapts during gender-affirming hormone therapy with testosterone treatment (1/15) nature.com/articles/s4158…

2021 #MichelsonPrizes: Next Generation Grants recipient Dr. Camila Consiglio and colleagues published their innovative research on gender-affirming testosterone treatment in nature. This study represents significant progress toward understanding sex hormones and the biology of

Congratulations to Petter Brodin, 2021 #MichelsonPrizes recipient Camila Rosat Consiglio, and all their colleagues on their publication in nature.

Our perspective on immunological studies in individuals undergoing Gender-affirming hormone therapy (corrected figure legend): nature.com/articles/s4157…

Sex Differences in Medicine: jci.org/review_series/… Biological sex influences disease risk, progression, & treatment. This review collection, edited by Dr. Barbara Stranger, highlights the potential to leverage sex-dependent mechanisms to optimize therapies across medicine