In a new preprint led by the talented Irika, we wanted to quickly share some unexpected results from our lab: the FDA-approved antifungal ciclopirox can induce TDP-43 cryptic exons seen across many brain diseases. 1/8 biorxiv.org/cgi/content/sh…

Excited to share this review on one of my favorite biological problems: Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms. Out in Nature Rev Neurosci today! nature.com/articles/s4158…

When Brian Wallach was diagnosed with ALS, he was given six months to live. Brian Wallach and Sandra Abrevaya’s film, For Love & Life: No Ordinary Campaign, chronicles their incredible journey, and proves that all of us are far more powerful than we know. I hope you’ll watch it on Prime

Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study NatureStructMolBiol developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn

Thrilled to share our MultiMap paper is now published online on Science. Science Magazine With Jim Wells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. science.org/doi/10.1126/sc…

Do you know how the #ALSIceBucketChallenge impacted #ALS research? The Ice Bucket Challenge, combined with the Brain Canada partnership, sparked an unprecedented influx of over $20 million to the ALS Canada Research Program. Join us in making a splash and take on the challenge!

Happy to share our latest preprint where we report interesting properties of the understudied "big tau" isoform that appears to evade pathological changes in the brain 🧠 1/n 🔗 to our bioRxiv preprint here: biorxiv.org/content/10.110…

I'm excited to share that our new paper on modeling Alzheimer's disease was published today in Science Magazine . I'm extremely grateful for the tremendous support and guidance from my mentor, Dr. Andrew Yoo WashUDevBio WashU Center of Reg Med and fantastic coauthors.science.org/doi/10.1126/sc…,