Interested in the fascinating field of microproteins? Join my group in a collaboration with Sebastiaan van Heesch at the PMC. PostDocs apply below: werkenbijprinsesmaximacentrum.nl/en/vacancy/pos… HeckLab PrinsesMáximaCentrum

YES! My group has been selected to join Oncode Institute, starting in 2024! 🍾🎉🥳 Proud of the team, exciting times ahead!!!

.Sebastiaan van Heesch is benoemd tot junior Oncode Institute onderzoeker 👏 Hij gaat kijken naar micro-eiwitten, hun rol in het ontstaan van kanker, en hun potentieel op het gebied van nieuwe immunotherapieën voor kinderkanker. Gefeliciteerd! research.prinsesmaximacentrum.nl/nl/news-events…

Had a great time presenting our van Heesch Lab & John Prensner lab work on the “dark proteome” at the #DarkGenome 2023 symposium in London. Great setup for a meeting, met many new people, received good feedback. Thanks Enara Bio Nucleome Therapeutics ROME Therapeutics for organizing & inviting me!

Happy to share our latest bioRxiv from Hopp-Kindertumorzentrum Heidelberg (KiTZ) and @dkfz on Genomic and phenotypic stability of fusion-driven pediatric Ewing #sarcoma cell lines biorxiv.org/content/10.110… Great collaboration with many friends of the Ewing field!

We recently announced that ten Junior Investigators and their research groups are invited to join Oncode Institute per January 1st, 2024. In the coming period, we will introduce them all to you! Meet Sebastiaan van Heesch, van Heesch Lab from PrinsesMáximaCentrum research.prinsesmaximacentrum.nl/en/news-events…

New preprint from the lab just in time for the new year! 🎉 Ribo-seq is a powerful method for discovering unannotated microprotein-coding smORFs, but it is only as effective as the software tools used to analyze the data. Does which tool you choose matter?

New research in Molecular Cell shows the important role of micro-proteins in the childhood brain tumor, medulloblastoma. The findings could in future lead to new, targeted treatments tackling the disease at a molecular level van Heesch Lab Michigan Medicine ➡ research.prinsesmaximacentrum.nl/en/news-events…

Online Now: Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma dlvr.it/T0wFq8

Interesting new article in Molecular Cell describing noncanonical open-reading frames (ORFs), microproteins and the translatome in cancer cell survival. While the example is medulloblastoma, it will be important to study in different tumor types👇 Translation of non-canonical

NEW PAPER👇 How do microproteins orchestra cancer? Check it out and see for some nifty work in #medulloblastoma. So proud of Damon Hofman J Ruiz Orera and Sebastiaan van Heesch for collaboratively leading this work, now out in Molecular Cell University of Michigan Michigan Medicine U-M Rogel Cancer Center UMich RNA Center 〽️🧬

If you want to follow more conversation, check out the MICROPROTEINS feed on Bluesky --> it's the new place to hear more about it. cell.com/molecular-cell…

A beautiful study emphasizing the importance of non-canonical ORFs and the encoded microproteins in cancer research. Elegant CRISPR screens identify a microprotein necessary for medulloblastoma cell survival. Congratulation John Prensner and Sebastiaan van Heesch!

What a great way to start 2024: Damon Hofman’s first co-first paper in our group got published today at Molecular Cell. Fantastic collaboration with J Ruiz Orera & John Prensner, plus all others involved! PrinsesMáximaCentrum

Thrilled to see our latest paper published in Molecular Cell! It has been a joy to work on this exciting research on the role of microproteins in #medulloblastoma, a collaboration led by Damon Hofman Sebastiaan van Heesch (van Heesch Lab) and John Prensner. 👇

Beautiful study by Sebastiaan van Heesch and John Prensner ! clever CRISPR tiling for functional uORFs👏👏👏 cell.com/molecular-cell…

Very interesting findings, a subset of translated uORFs that maintain cancer cell survival. Agree with your recommendation for the inclusion of non-canonical ORFs in cancer genomics studies. Well done to all involved Damon Hofman, J Ruiz Orera, Sebastiaan van Heesch, John Prensner... #Riobseq

1/ Did you know the genome might have hidden protein-coding genes? In the 25 years since the Human Genome Project, research has been tied to a consensus set of 20,000 protein-coding genes. But the ‘dark genome’ has ‘dark proteins’ lurking in plain sight. biorxiv.org/content/10.110…

Interested in the "dark" proteome? Very excited to see this preprint out! One of the first of (hopefully) many new collaborations on the Ribo-seq ORF consortium. Check it out below! 👇

1/ Did you know the genome might have hidden protein-coding genes? In the 25 years since the Human Genome Project, research has been tied to a consensus set of 20,000 protein-coding genes. But the ‘dark genome’ has ‘dark proteins’ lurking in plain sight. biorxiv.org/cgi/content/sh…