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Mapping the Lickability of the Periodic Table

Happy Friday! I want to elaborate on a thought provoking discussion from last night’s Kendall Square panel AI in drug discovery featuring Derek Lowe, Jen Nwankwo, Alex Snyder, and me (thx Rhie Lim/CIC for organizing!) It should interest techbio/biotech VCs and founders-to-be: 🧵

This is neat. Hydrogen peroxide-independent proxmity labeling for in vivo interactome mapping. Currently limited to extracellular applications due to copper-dependent activity. Clever use of a membrane impermeable tyrosinase substrate. biorxiv.org/content/10.110…

Oof.

My postdoc days, October, 2010 - certain I was applying for A LOT of jobs, on top of doing science AND being a parent to a 3yo... To all the parents of little ones readying faculty job apps, I know this is a whole new level of stress - so I wish you the VERY best of luck.🤞

Super interesting discussion 🧵 on limitations of AF, although IMO (😉) it should lead with a link to the work catalyzing the conversation 'how does Alphafold know how to fold' - NIH Intramural Lauren Porter 👇 nature.com/articles/s4146…

Thrilled to share our latest story Nature Cell Biology on a new way to control protein localization without exogenous triggers (e.g., light/rapamycin)—take advantage of endogenous triggers in dividing cells! Free link: rdcu.be/dSlrS Regular link: nature.com/articles/s4155… 1/4

Final version of paralogue-specific EP300 degrader story now out at JACS Au. Congrats to Xuemin Chen, McKenna Crawford, Ying Xiong and our many amazing collaborators ChemBioHub - Huber Lab pubs.acs.org/doi/10.1021/ja…

Derek Lowe has been sharing his opinions on biomedical research to a global audience for over 20 years. Here, with grace and good humour, he takes a tour some of his most spectacular misses. chemistryworld.com/opinion/being-…