Age-related epithelial defects characterized by features of epithelial-to-mesenchymal transition linked to reduced FOXN1 limit thymic function and regeneration Nature Immunology Dudakov Lab van den Brink Lab nature.com/articles/s4159…

New work from Fred Hutch's Dudakov Lab, @wehi_research's Daniel Gray, Marcel van den Brink et al published in Nature Immunology reveals non-functional cell that accumulate in aging thymus, "offer an innovative target to therapeutically boost thymic function." bit.ly/4dbZ8Sd

Dudakov and colleagues report the age-associated emergence of unique TEC states linked with tissue degeneration. Read it here: rdcu.be/dQQla nature.com/articles/s4159…

Help get me on stage at @SXSW ’25 by voting for my panel, “Guardians of Youth: Stems Cells & Human Longevity.” Visit: bit.ly/3YKsCCf before Sunday night. #SXSW #Longevity #HealthyAging #Healthspan #AntiAging

Excited to share our review on thymic selection and how the two stages of negative selection shape the thymic microrepertoire!

Congratulations to the authors on this inspiring publication! We fully agree that strategies counteracting thymic aging and and its decline in function could have big implications for human health. Anastasia I. Kousa et al. Marcel van den Brink Dudakov Lab nature.com/articles/s4159…

Omg, our paper was selected for the Nature Immunology cover with the amazing "Black Hole Thymus" illustration by DrawImpacts

New Cover for Nature Immunology : 🕳️🏙️ Thymic involution and immune aging! Dudakov Lab and colleagues identify changes in the mouse thymic stromal compartment associated with age and injury and find age-related thymic epithelial cells that form a non-functional microenvironment in

Sure to be a great meeting. I was fortunate to have participated at a previous iteration and it was fantastic!

Thrilled to announce that our latest research at CIML showing that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development is out in Nature Communications Link: rdcu.be/dSGOW @Irlalab Borelli Alexia Rafa Argüello #Treg #Thymus #Tcells #Immunology

Very cool approach: investigating effects of sex steroids on immune function using patients undergoing gender-affirming care. Very surprised to see only minimal difference in naive T cells but curious to know if this would also be reflected by TRECs!

What sorcery is this? science.org/doi/10.1126/sc…

Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence nature.com/articles/s4358…

DNA replication dynamics in regenerating mouse livers unveil aging-dependent decline in replication efficiency and a crucial role of the ATR checkpoint kinase in mitigating inflammation associated with the decline Cell Deborah Keogh-Stroka Halazonetis cell.com/cell/fulltext/…

REVIEW Nature Rev Immunol Antigen presentation for central tolerance induction nature.com/articles/s4157…