T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study | Cancer Discovery | American Association for Cancer Research aacrjournals.org/cancerdiscover…

Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, Liling Wan, and colleagues. Penn Medicine Penn Medicine - Abramson Cancer Center Penn Epigenetics Univ. of Pennsylvania Department of Cancer Biology bit.ly/4cTwIvw

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Excited to see our paper officially out in the August issue of Cancer Discovery !

Read Cancer Discovery's #ResearchWatch: Macrophages Scavenge Myelin to Support Glioblastoma Metabolism. bit.ly/4790Rpr

Thank you EACR for highlighting our work on breast cancer bone metastasis! New immunotherapy combinations are the way to combat #metastasis. Lea Monteran Cancer Discovery magazine.eacr.org/highlights-in-…

Editorial by Müschen Lab Coraline Mlynarczyk and colleagues in Cancer Discovery puts together the results from these studies with emphasis on druggability 💊Highlights on how they align with Pola-V benefit seen mostly in ABC/MCD DLBCL and how KLHL6 could be targeted to sensitize others

August Editors’ Picks from the 10 AACR journals include a “colon-age” metric for personalizing colorectal cancer screening, a look at how violent environments affect stress signaling in lung tumors, and more. Learn more on the #AACRBlog: bit.ly/3XsWRge

Read the article: Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity. bit.ly/3Xu17fe

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate #Glioblastoma Growth through Stabilizing BRD2, Lishu Chen, Qinghui Qi, Xiaoqing Jiang, Jin Wu, Tao Zhou, Jianghong Man, et al. bit.ly/3zh7CZz #NanhuLaboratory #NationalCenterofBiomedicalAnalysis.

I'm super excited to see our work featured on the cover art of the September issue of Cancer Discovery Cancer Discovery. aacrjournals.org/cancerdiscover… Artwork by Bianca Dunn

Thank you so much Cancer Discovery and Elizabeth McKenna for choosing our study for a #ResearchWatch, and capturing so well the essence of our message in it! We’re very excited about the highlight :) Daan J. Kloosterman The Netherlands Cancer Institute

The September issue of Cancer Discovery is now online! The cover features work by by Jitendra K Meena, Westbrook Lab and colleagues showing MYC induces oncogenic stress through RNA decay and ribonucleotide catabolism. That and much more here: aacrjournals.org/cancerdiscover…

AACR NextGen Star Future Directions commentary is out! Thank you to the AACR for this fantastic opportunity to write about integration of immune profiling into epidemiologic studies #epitwitter aacrjournals.org/cancerdiscover…

Congrats on your award NextGen ⭐️award Claire! Exciting to have our collaborative work on CRC epidemiology, molecular features, and the immune microenvironment highlighted in Cancer Discovery.

‼️ The final version of our article “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out in Cancer Discovery Cancer Discovery: aacrjournals.org/cancerdiscover… Learn more about our findings in this thread 👇🏽

Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH Great team work by Santi Demajo Meseguer, Joan Enric Ramis Z, Ferran Muiños et al Tweetorial 👇

Check also the Views paper on our work written by Christopher Arends and Siddhartha Jaiswal Thanks for the accurate summary and perspective on our work Siddhartha Jaiswal aacrjournals.org/cancerdiscover…

A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in mBRAF Cancers Using Pharmacokinetics-Informed Dose Escalation Cancer Discovery doi.org/10.1158/2159-8… 👏efficient dose escalation concept 👉compelling activity in resistent pts 🤩great to see the new generation