In vitro and in vivo inhibition of the host TRPC4 channel attenuates #ZikaVirus infection By X. Chen, Y. Yan, Z. Liu, S. Yang, A. Obukhov, R. Cao, W. Zhong & colleagues at Beijing Institute of Pharmacology and Toxicology & IU School of Medicine 🗞️doi.org/10.1038/s44321…

Immune-enhancing #neutrophils reprogrammed by subclinical low-dose #endotoxin in #CancerTreatment By Y. Zhang, L. Li & colleagues Virginia Tech VT Biology ➡️doi.org/10.1038/s44321…

DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells. #myoblasts #rhabdomyosarcoma #EwingSarcoma 👉doi.org/10.1038/s44321… by J. Rich, B. Geoerger, I. Pirozhkova & colleagues Gustave Roussy Institut Cochin

Our academic editor Yehu Moran is attending #Evol2024 in Montreal from 26-30 July. If you’re attending, please join him July 27th from 12:45-13:45 as he introduces our journals’ portfolio expansion in #ecology and #evolution. SSE Society of Systematic Biologists ESEB American Naturalist Evolution Meetings

LILRB1-HLA-G axis defines a checkpoint driving #NaturalKillerCell exhaustion in #tuberculosis By Y. Pang, G.F. Gao, C.H. Liu & colleagues at Chinese Academy of Sciences, China 🗞️doi.org/10.1038/s44321…

📢PD-1/LAG-3 co-signaling profiling uncovers CBL ubiquitin ligases as key #immunotherapy targets. #Tcells #LungCancer By L. Chocarro, E. Blanco, D. Escors & colleagues Navarrabiomed IdiSNA Navarra ➡️doi.org/10.1038/s44321…

New #publication in EMBO Mol. Medicine, scientists Institut Cochin (Iryna Pirozhkova's group) & Gustave Roussy describe DiPRO1 protein as a new potential therapeutic target in pediatric #mesenchymal #Cancers institutcochin.fr/en/news/new-th… CNRS Biologie Inserm CNRS Île-de-France Villejuif Université Paris Cité

#Dantrolene corrects cellular disease features of #DarierDisease and may be a novel treatment. By M. Hunt, N. Wang, E. Bachar-Wikstrom, J. Wikstrom & colleagues Karolinska Institutet 🗞️doi.org/10.1038/s44321…

The RhoB p.S73F mutation leads to #CerebralPalsy through dysregulation of #lipidhomeostasis. By X. Wu, R. Liu, L. Lai, Y. Song, Z. Li at Jilin University, Changchun ➡️doi.org/10.1038/s44321…

📢The ASC #inflammasome adapter governs SAA-derived protein aggregation in inflammatory #amyloidosis By M. Losa, Adriano Aguzzi & colleagues Unispital_USZ 👉doi.org/10.1038/s44321… Read also related News & Views by S. Maasewerd & B. Franklin Rheinische Friedrich-Wilhelms-Universität Bonn 👉doi.org/10.1038/s44321…

👩‍🔬Researchers from the #OncoImmunology Unit of @Navarrabiomed have identified one of the major mechanisms of resistance to PD-1/PD-L1 blockade #immunotherapy 📰 Published by EMBO Mol. Medicine doi.org/10.1038/s44321… Open thread!👇 navarrabiomed.es/en/actualidad/…

Therapeutic targeting #ERRγ suppresses metastasis via #ExtracellularMatrix remodeling in #SmallCellLungCancer. By H. Wang, H. Sun, J. Huang, X. Lu, W. Feng, J. Wang & colleagues at Guangzhou, China ➡️doi.org/10.1038/s44321…

Finally out EMBO Mol. Medicine: our study exploring a new way of experimental #vaccination for #malaria using attenuated #parasites and featuring antibodies, CD4 + CD8 T cells, interferon + interleukins. Soon we'll be immunologists; high time to start surfing: embopress.org/doi/full/10.10…

Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical #mousemodel of #CTNNB1 syndrome. #NeurodevelopmentalDisorder By J. Alexander, M. Jacob & colleagues TuftsGSBS 🗞️doi.org/10.1038/s44321…

The #MondoA -dependent TXNIP/GDF15 axis predicts #oxaliplatin response in #ColorectalCancer. By J. Deng, T. Pan, R. Beatson, T. Ng & colleagues Queen Mary University of London King's College London UCL 👉doi.org/10.1038/s44321…

🦟Experimental #vaccination by single dose sporozoite injection of blood-stage attenuated #malaria parasites🦟 By J. Sattler, F. Frischknecht & colleagues Freddy Frischknecht ➡️doi.org/10.1038/s44321…

Finally out!🎉Very excited to share that we have just published part of my PhD research! We have identified PD-1/LAG-3 molecular mechanism of co-signaling, and tripled survival in mouse models of lung cancer refractory to immunotherapies, reverting PD-1/LAG-3-mediated resistance.

Online today! Comprehensive molecular characterization of #CollectingDuctCarcinoma for therapeutic vulnerability. By P. Guan, J. Chen, C. Mo, T. Fukawa, X. Yao, B. T. Teh, J. Tan & colleagues Genome Institute of Singapore & Sun Yat-sen University Cancer Center China 🗞️doi.org/10.1038/s44321…

🆕Learn more about #researchintegrity in a friendly + interactive setting. Sign up for "Scientific integrity: how to publish reproducible results": lab-management.embo.org/dates/sci-inte… Ieva Gailite The EMBO Journal provides insights + offers a unique angle from EMBO Press #editor's point of view