Antibiotic Steward Bassam Ghanem🆔🌟 Arturo Casadevall has been writing on this in the context of fungal infections
doi.org/10.1128/mBio.0…

Nico Cortes-Penfield MD FACP 🦴💊 Antibiotic Steward Bassam Ghanem🆔🌟 #IDtwitter Related to global total disease burden is ecosystem degradation, biodiversity loss, and emerging zoonotic diseases. Integral to caring about basic human rights, such as to life, food, water, sanitation, health, and education, is caring about a healthy global climate!

Antibiotic Steward Bassam Ghanem🆔🌟 Poverty, breakdown of critical sanitation and transportation/supply chain infrastructure (including drugs and other medical supplies), mass displacement of populations in areas affected by drought, flooding, and/or lethal wet bulb temperatures.

Otherwise it should be fine though

Strengthening the global response to climate change and infectious disease threats.
✨Excellent infographic✨ The BMJ #IDTwitter
bmj.com/content/371/bm…

This is scary,ID/climate change
>100 diverse microorganisms in Siberia’s deep permafrost have been found to be antibiotic resistant😳
As the permafrost thaws,there is potential for these bacteria to mix w meltwater & create new antibiotic-resistant strains nature.com/articles/s4155…

Climate change is adversely affecting the burden of infectious disease throughout the world, which is a health security threat
Fantastic 🆕💥💥Review Infectious Diseases and Therapy
Climate Change and Cascading Risks from Infectious Disease #IDTwitter #MedEd #TwitteRx
link.springer.com/article/10.100…

Does wearing a face mask lead to increased hand-to-face contact in children?
The Back-to-School COVID-19 Simulation Randomized Clinical Trial might provide an answer! JAMA Pediatrics #IDTwitter #MedEd
jamanetwork.com/journals/jamap…

Rare but fatal!
🆕⚡COVID-19 Associated with Cryptococcosis: A New Challenge during the Pandemic #IDTwitter #MedEd #TwitteRx
mdpi.com/2309-608X/8/10…

Source control is paramount!
In univariate analysis, early or late focus control and adequate targeted therapy were associated with lower in-hospital mortality, while only early or late focus control was significantly associated with a protective effect for 90-day mortality

Performing follow-up blood cultures and appropriate duration of therapy were not significantly associated with mortality; these interventions might be more closely related to the risk of relapse or late complications #IDTwitter #MedEd #TwitteRx

Focus control was ultimately performed in only 37.5% of patients in whom it was formally indicated
No follow-up blood cultures were performed in up to 33% of patients, and almost 40% of complicated SAB cases received less than 28 days of treatment. #IDTwitter #MedEd #TwitteRx

It's complicated!
Are antifungal agents associated with lower rates of mortality when administered before definitive diagnosis of an invasive fungal infection in critically ill patients without neutropenia? #IDtwitter #MedEd #TwitteRx link.springer.com/article/10.100…

I do remember! That's the power of WikiGuidelines. We don't push our 'expert' beliefs on others. We let the data do the talking. High quality, reproducible data, we make a Clear Recommendation. Not? We discuss options suggested by lower quality data.

Antibiotic Steward Bassam Ghanem🆔🌟 Glad to have PK data back up clinical. For higher MIC Staph though, I have to say 600 QID of clinda would not be easy for patients. Maybe 900 tid instead? Still not easy.

Ledaborbactam (formerly VNRX-5236) #IDTwitter #MedEd #TwitteRx

🆕⚡⚡ #JACnews
In vivo pharmacokinetics and pharmacodynamics of Ceftibuten/ledaborbactam etzadroxil
A game changer oral antibiotic = oral CZA🤓
Ledaborbactam restored ceftibuten activity against Ambler Class A-, C- and D-producing Enterobacterales + ESBL
academic.oup.com/jac/advance-ar…

#IDtwitter
« An important limitation of traditional clinical guidelines is the frequent dissociation between quality of evidence and strength of recommendations.
As a result, some past guideline recommendations have endorsed harmful care, (…) »