"As a society, we must think critically and act collaboratively to both understand and relieve the exclusivities arising from current health-care delivery models" #sicklecell #genetherapy NEW Comment by Akshay Sharma MD & Tami D John thelancet.com/journals/lanha…

Last year we published in Blood Journal that diffuse myocardial fibrosis was very common in individuals with sickle cell disease and that hydroxyurea and blood transfusions did not prevent it, even if these were started at a young age. ashpublications.org/blood/article/…

My friend Akshay Sharma MD St. Jude Research St. Jude gave an important talk during the @sbtmo meeting! Gene therapy for SCD in Brazil : is this a just a dream or can it be a reality? Although it’s still extremely expensive, after his talk I looked at the problem in a different way🔝

Addressing #SickleCellDisease in India.. Fantastic piece by Priyanka Runwal C&EN (Chemical & Engineering News) cen.acs.org/pharmaceutical…

Akshay Sharma MD @akshaysharma.bsky.social and Tami D John discuss how the current paradigm of developing and distributing ultra-expensive gene therapies, such as those recently approved for sickle cell disease, is unsustainable and how we can make these therapies more accessible.

"As a society, we must think critically and act collaboratively to both understand and relieve the exclusivities arising from current health-care delivery models" #sicklecell #genetherapy ICYMI Comment by Akshay Sharma MD & Tami D John thelancet.com/journals/lanha…

Impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell disease ow.ly/xias50SU489 #clinicaltrialsandobservations #pediatrichematology #redcellsironanderythropoiesis #sicklecelldisease #tranplantation

Randomised trial of blood delivered by courier vs drone between two hospitals 70km apart. No difference in quality between the two groups. Paper in British Journal of Haematology but behind a paywall. tinyurl.com/4dhwkjzf

Honored to present 🇮🇳's 1st CAR T journey collab IIT Bombay Rahul Purwar Tata Memorial Hospital Hasmukh Jain ImmunoACT NCI Center for Global Health & Roadmap ahead in presence Hon'ble Health Minister Dr Jitendra Singh Ministry of Health DBT-BIRAC #NationalBiopharmaMissionConclave🙏 CAR-T & Cell Therapy Centre (CTCTC) ACTREC_TMC Albeena Nisar

Speaking of overcoming disparities, a nice ASTCT graphic this week about how to operationalize outpatient CAR-T: 1️⃣ Set up your team 2️⃣ Set up your clinic 3️⃣ Choose your patients #2 often gets less attention than #1 & #3, but all are important! astct.org/Nucleus/Articl…

I get review requests from all sorts of journals, but this one I just couldn’t refuse 🦖🪶

Congratulations to the authors 4 finally putting this decade-long ❓ to rest. Nature Medicine We can all sleep better (or worse 😬) tonight, knowing CH causes atherosclerosis & not the other way around. That’s some pretty “determinate” potential, I’d say 😉 TET2> DNMT3A & of

ASH is redefining ANC reference ranges based on Duffy status. No patient should face uncertainty in their medical treatment because of their genetics. #ASHDEI #HealthEquity

Thanks to JCO Oncology Practice for publishing the flagship manuscript from our National Cancer Institute funded RIGHTime study - elevating the voices of children with cancer and their families to improve communication and care. Justin Baker #AcademicTwitter

From the first discovered case to FDA-approved gene therapies, we have over a century of milestones in research and treatment for sickle cell disease. Check out our interactive timeline: ow.ly/MolQ50TnbzT #Sicklecell #SickleCellAwarenessMonth #ConquerSCD

ASTCT and CIBMTR are excited to announce that registration is now open for #Tandem2025! Register now to join us Feb. 12-15, 2025, for four days of scientific updates, clinical trials, groundbreaking research and more. See you in Hawaii 🌺🏝️🐬 tandemmeetings.com