Extremely grateful for support from my family, mentors, and colleagues, especially MVH Lab Koch Institute at MIT, Alex Toker BBS at Harvard, Henrik Dohlman UNC-Chapel Hill, that made this possible. Special thanks to my wife Rachel and daughter Rose for encouraging and supporting me. Thank you!

Thank you George!!

1/19 Check out the full tweetorial for our new paper in nature - open access! “PI3K drives the de novo synthesis of coenzyme A from vitamin B5” Collaboration between Dibble lab Dibble Lab and Toker lab Alex Toker at BIDMC BIDMC and HMS Harvard Medical School nature.com/articles/s4158…

Read this week's Cancer Discovery #ResearchWatch, PI3K-AKT Inhibits PANK4 to Promote De Novo Synthesis of Coenzyme A, a summary of the paper by Dibble Lab, Sam Barritt, Alex Toker et al. bit.ly/3dbUeuA BIDMC Harvard Medical School BBS at Harvard

Last issue on #metabolites in pathological #microenvironment and #immunometabolism! Happy reading! Biomed News Immunometabolism Network 👉🏼biomed.news/bims-mepmim/20… My highlight: PI3K–AKT and metabolite-mediated feedback regulate flux through de novo CoA synthesis Dibble Lab Alex Toker

#NatMetabPicks | In nature, Alex Toker, Dibble Lab et al (Harvard Medical School) show that the PI3K-PANK4 signaling axis regulates de novo coenzyme A synthesis, abundance of acetyl-CoA & CoA-dependent processes, which coordinate cellular CoA supplies. #metabolism nature.com/articles/s4158…

So excited to share the HCI Frontiers Symposium in Signaling coming on September 30th! Check out the incredible speakers: Dr. Katerina Politi Rushika M. Perera Donita Brady of Brady Lab UPenn Charles Sawyers @Poulikakos_Lab Alex Toker Heather Christofk Huntsman Cancer Institute Can't wait!

Join our team! Recently received some very good funding news and have openings for new postdocs. Drop me an email that describes what areas you might be interested to study in our lab. PI3K-mTOR signaling network in health and disease. #cancermetabolism hsph.harvard.edu/manning-lab/ma…

SLC5A6 imports pantothenate into the cell to positively regulate CoA production. PANK4 is a phosphatase and negative regulator (see the fascinating recent paper from Alex Toker and colleagues x.com/alex_toker/sta….) (10/15)

Drs. Christian Dibble's (Dibble Lab) & @Alex_Toker's labs revealed a direct regulatory connection between one of the major regulators of growth and metabolism, the #PI3K signaling pathway, and one of the most critical metabolic cofactors, #CoenzymeA. 🔗 bit.ly/3pj6xbh

Great day of hiking in a rather dehydrated Blue Hills Reservation. Annual joint Manning-Dibble-Toker lab hike and Trillium Brewery trip. With two thirds of the ⁦TheManningLab⁩ newborn boys making an appearance. ⁦Dibble Lab⁩ ⁦Alex Toker⁩

Congratulations to this amazing young man and magnificently talented scientist, Sam Barritt who yesterday defended his PhD thesis in the BBS graduate program at Harvard Medical School. Congrats Dr. Barritt!!

Amazing day of great science with many friends and colleagues, thank you for the invite!

Here's Laurel Oldach's story about today's #NobelPrize winner, Svante Pääbo, who pioneered the field of paleogenetics. asbmb.org/asbmb-today/pe…

Congratulations to ASBMB member Carolyn Bertozzi and colleagues Morten Meldal and Barry Sharpless on receiving today's Nobel Prize in Chemistry for their work in click/bio-orthogonal chemistry!

My lab Univ. of Pennsylvania Department of Cancer Biology in Penn Medicine is recruiting postdoctoral fellows to interrogate the intersection of metal availability, mitogenic and nutrient signaling, and metabolism in cancer! We’d love to have you join us! Details below & Cell Career Network Biomedical Postdoctoral Programs.

This is huge. Capivasertib will almost certainly be the first AKT inhibitor to be approved. In ER+ve BCa. I have been waiting almost 30 years for this news. astrazeneca.com/media-centre/p…

If you're looking for an amazing lab to join in 2023 then look no further! Apply to join the Madsen lab MRC PPU without delay. A brilliant scientific experience on all fronts. Thinking of applying myself!

During #AANHPI23, we highlighted our grantees' stories about their careers in cancer research. We’ll continue to share their stories this month & beyond. In Dr. Jan Heng's video below, she discusses the moment that inspired her to work in transgender cancer research. BIDMC

The #PI3K Biochemical Society meeting in not-so-sunny Barcelona is closed by keynote speaker Alex Toker. A fantastic overview of the mechanisms and therapeutic potential of targeting the PI3K and AKT pathway in cancer to finish an excellent conference.