Great to see Amy Hughes work on bioRxiv! If you are interested in CpG islands and transcription regulation check this out. Amy finds an interesting new role for CpG islands and SET1 complexes in counteracting termination by ZC3H4 complexes.👇 biorxiv.org/content/10.110…

Wonderful team effort from Aleksander Szczurek Jess Kelley Anna Lastuvkova Emilia Dimitrova Neil Blackledge .

Ever wondered why the majority of mammalian gene promoters are embedded within CpG islands? Check out this beautiful work by Amy Hughes showing that a protein complex which binds to CGIs protects genes from premature transcription termination! biorxiv.org/content/10.110…

Amazing job by Amy Hughes and Rob Klose team unveiling an unexpected role for SET1 complexes in transcription regulation of CpG island-containing genes. Congrats!

Great to see all of Amy Hughes hard work finally out in the world! This project took several turns we didn't expect but came together into a really interesting story!

Really excited to see some of the work from my PhD in the Rob Klose lab on BioRxiv! Thank you to all of the co-authors and all members of the Klose lab, past and present, for all of the help along the way!

Great job from Joe Bowness and co getting into the fine details of how X chromosome inactivation process works in differentiation. Now out in Cell Reports

I’m very proud of Amy Hughes and the rest of the team Department of Biochemistry at Oxford University on the final published version of our paper Nature Communications !🍾🎉 nature.com/articles/s4146… a few details about the paper below if you are interested👇

1/6 I'm pleased to announce new preprint on how Polycomb system controls transcription in living cells by myself, Rob Klose, Emilia Dimitrova , and Jess Kelley biorxiv.org/content/10.110…

Are you keen on discovering how chromatin regulates gene transcription? kloselab.co.uk are looking to recruit PhD students to join our team! If you are interested, there are links in the thread below to the application process and funding opportunities. Please RT!