Ben Lehner
@benlehner
Head of Generative and Synthetic Genomics @sangerinstitute;
Systems + Synthetic Biology @CRGenomica;
Co-founder barcelonacollaboratorium.com allox.bio
ID: 28628202
https://www.sanger.ac.uk/programme/generative-and-synthetic-genomics/ 03-04-2009 19:03:48
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Excited to share Albert Escobedo's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with Andre Faure @[email protected] Centre for Genomic Regulation (CRG) Wellcome Sanger Institute biorxiv.org/content/10.110…
Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new Royal Society Publishing biographical memoir: royalsocietypublishing.org/doi/10.1098/rs…
We have a tenure track opening for a computational scientist with exciting ideas for #machinelearning in molecular biology at the MRC Laboratory of Molecular Biology, incl generous core funding from Medical Research Council & an unparalleled scientific environment. RTs appreciated! 🤗 jobs.sciencecareers.org/job/657824/res…
Interpretably deep learning amyloid nucleation by massive experimental quantification of random sequences new preprint by Mike-no twitter-Thompson with Mariano Martín, Peter Koo and Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC biorxiv.org/content/10.110…
Presenting the first large-scale measurement of energetic couplings for a protein transition state! biorxiv.org/content/10.110… with Anna Arutyunyan Mireia Seuma Andre Faure @[email protected] & Ben Lehner
Very, very happy to finally share this: Energetic portrait of the amyloid beta nucleation transition state Anna Arutyunyan Mireia Seuma Andre Faure @[email protected] Benedetta Bolognesi Wellcome Sanger Institute Centre for Genomic Regulation (CRG) IBEC biorxiv.org/content/10.110…
Ignasi Ignasi Toledano paper now out in Nature Genetics! "Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules" Deep mutagenesis used to study which mRNA sequence contexts promote🛑mut rescue by🧪 Great collaboration w/Ben Lehner lab
A much improved version of this, today out in Nature Genetics ! with Ben Lehner and Fran Supek nature.com/articles/s4158…