The EMBO Journal
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Rapid publication of research in molecular, cell & organismal biology.
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http://emboj.embopress.org 04-12-2013 15:12:52
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PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis Ippei Shimizu Ippei Shimizu and coworkers embopress.org/doi/full/10.10…
The unfolded protein response regulates ER exit sites via SNRPB-dependent RNA splicing and contributes to bone development Loydie Jerome-Majewska Loydie McGill University, Hesso Farhan Hesso Farhan Med. Uni. Innsbruck and coworkers embopress.org/doi/full/10.10…
It was a pleasure to write this The EMBO Journal news and views about two wonderful papers from Tom Deegan and Karim Labib: embopress.org/doi/full/10.10… I highly recommend these papers. Thanks to Hartmut Vodermaier for the opportunity! 🫶🧪
Insulin-responsive GLUT4 secretion requires a designated clathrin isoform, CHC22, which is specifically recruited through its interaction with the trafficking proteins p115 and SNX5 Joshua Greig Joshua Greig Frances Brodsky et al embopress.org/doi/full/10.10…
Andreas Strasser, Gemma Kelly and colleagues WEHI (Walter and Eliza Hall Institute) present several new knock-in mouse models for the study of differential TP53 responses and contributions to apoptosis or cell-cycle arrest embopress.org/doi/full/10.10…
Does the 9-year-old unifying hypothesis still hold–that an increased number of mutant myosin available for actin binding causes cardiac hypercontractility? Yes, say Ruppel, Spudich et al Stanford Medicine upon reviewing recent structural & enzymatic analyses! embopress.org/doi/full/10.10…
STIC2 is a newly-identified interaction of ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins, in particular photosystem reaction center protein D1 Danja Schunemann and colleagues Ruhr-Universität Bochum embopress.org/doi/full/10.10…
A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma Peter Sims Peter Canoll Columbia University et al find quiescent astrocyte-like glioma cells show abnormal energy metabolism, sensitizing them to ferroptosis-inducing drugs embopress.org/doi/full/10.10…
A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth Björn von Eyss et al von Eyss lab Leibniz-Institut für Alternsforschung (FLI) embopress.org/doi/full/10.10…
🚨 New paper in The EMBO Journal! The Karagöz lab has uncovered how IRE1, a crucial transmembrane protein, responds to protein folding stress in the ER and reveals that disordered regions in the luminal sensor domain play a vital role in its self-assembly ➡️ tinyurl.com/4jdm5p6x
Issue 17 highlights: LINE1 stimulating host bone repair TNFR Wengen in tissue regeneration And… …PP2A governs cytokinetic abscission in Toxoplasma …CDK1 phosphorylation of TDP1 for repair of Top1-DNA complexes ... Sandra Krahl cover for Carmit Levy et al embopress.org/toc/14602075/4…
Disordered regions in the IRE1α ER lumenal domain form condensates in vitro and mediate its stress-induced clustering and signaling in cells Elif Karagöz Elif Karagöz Max Perutz Labs Vienna and coworkers embopress.org/doi/full/10.10…