Devimistat (CPI-613) With Modified Fluorouarcil, Oxaliplatin, Irinotecan, and Leucovorin (FFX) Versus FFX for Patients With Metastatic Adenocarcinoma of the Pancreas: The Phase III AVENGER 500 Study ⁦Journal of Clinical Oncology⁩ ascopubs.org/doi/10.1200/JC…

Clinical implementation of simultaneous multiple biomarkers testing for metastatic or recurrent gastroesophageal adenocarcinoma: a single-institutional experience - ESMO Gastrointestinal Oncology esmogastro.org/article/S2949-…

The GenomeSpy paper is now out, published in GigaScience! Check it out: doi.org/10.1093/gigasc…. GenomeSpy is a visualization toolkit for interactive genome visualizations, powered by GPU-accelerated graphics. #BioVis #Datavisualization #Bioinformatics #WebGL (1/5)

Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial ascopubs.org/doi/10.1200/JC…

Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2–Expressing Biliary Tract Cancer (HERB; NCCH1805): A Multicenter, Single-Arm, Phase II Trial ascopubs.org/doi/10.1200/JC…

💉Alternating gemcitabine plus nab-paclitaxel and gemcitabine alone in advanced pancreatic cancer ALPACA trial The Lancet Gastroenterology & Hepatology ➡️first line gem-nabpacli, 3x induction ➡️then randomized to -standard gem-nabpacli or -alternating gem-nabpacli/gem alone ✅mOS: 10.4 vs 10.5 mo ✅AE

LESS CODE, MORE RESULTS! 💪 Nonlinearity with Numeric Predictors in Logistic Regression Solved! Watch the video for more details: youtu.be/pHR07EuEKjM #rstats #statistics #dataanalysis #stats #datascience #r4ds #dataanalytics

Multiomics2Targets identifies targets from cancer cohorts profiled with transcriptomics, proteomics, and phosphoproteomics ⁦Cell Reports Methods⁩ cell.com/cell-reports-m…

An unforgettable moment, former Italian prime minister Mario Monti signed my copy of his book #Demagonia 🥹

“Do fewer things, work at a natural pace and obsess over quality” nature.com/articles/d4158…

Our new work from Köhler Lab is out on Liver International ‼️ 🔹 cell lines, organoids and mouse models of #cholangiocarcinoma 🔸 non-canonical NF-κB axis LTβ/NIK/RelB shown as driver of cancer initiation and therapeutic target Paula Hoffmeister-Wittmann Stefan Fröhling onlinelibrary.wiley.com/doi/10.1111/li…

It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!

#OpenAccess in Cancer Discovery by Dave Tuveson & team #PancreaticCancer organoids seem to predict patient-specific responses to chemotherapy and might provide a potential pathway for #PrecisionMedicine in #pancsm 💜 OncoAlert 🚨 aacrjournals.org/cancerdiscover…

Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer Cancer Cell cell.com/cancer-cell/fu…

Alternating gemcitabine/nab-paclitaxel and gemcitabine vs continuous gemcitabine/nab-paclitaxel after induction Tx of #PDAC The Lancet Oncology doi.org/10.1016/S2468-… 🔎 ALPACA phs 2, 325 pts 👉Similar OS, but improved tolerability 🧐Alternating schedule may be considered ESMO - Eur. Oncology

Pancreatic Cysts ⁦NEJM⁩ nejm.org/doi/full/10.10…

Omission of 5-FU Bolus From Multidrug Regimens 🔍Retrospective study with ~12,000 pts in GI cancer 💥Omitting 5-FU bolus had no negative impact on survival (FOLFOX, FOLFIRI, FOLFIRINOX) 💥Associated with a significant reduction in toxicity jnccn.org/view/journals/…

I found this review on protein isoforms, derived from alternative splicing, very interesting 👉most genes produce multiple protein isoforms🧬🔄 👉isoforms can be tissue-/disease-specific 👉potential for therapeutic modulation or for biomarker discovery nature.com/articles/s4157…

"It’s painful to hear them refer to us as if we’re living cancers and not living people." Persons with cancer rather than cancer patients - Semantics matter jamanetwork.com/journals/jamao…

NEW CONTENT Nature Cancer 'A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies' by Akbani, Mills, Liang and collaborators doi.org/10.1038/s43018…