For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

Mucins and the mucus barrier are major players in the colonic innate defense system against bacteria. But what about the small intestine, a major site of bacterial infections that can trigger chronic inflammation? Come & listen to my talk on Monday 5.00 PM -5.15 PM! #ICMI2024

Just saw this at #ICMI2024, very cool method mixing single molecule RNA imaging with expansion microscopy for gut bacteria

Have you ever wondered how often N- 🟦and O- 🟨glycans modify the same peptide? We did too! Check out our new preprint online now, spearheaded by Joann Chongsaritsinsuk with help from Valentina Rangel-Angarita, @keira_Erol, and Taryn Lucas! 🧵👇

Crazy stuff, read the full thread!

Gut-Brain axis: Gut microbial factors, including microbial networks and bidirectional host-microbe interactions, predict severity of multiple sclerosis. Check out our new paper in Nature Microbiology nature.com/articles/s4156….

Human Intestinal epithelial cell maturation fortifies the surface against Salmonella attack. Our new bioRxiv preprint presents the work of Jorik van Rijn and Ana Lopes with important contribs by colleagues Uppsala University and Göteborgs universitet / University of Gothenburg. Read: biorxiv.org/content/10.110…

New review out in Science Magazine from Jacob Wilde and Kevin Foster, that I had the honor to meddle in as the resident immunologist. What possibilities do hosts have to influence their microbiomes? May contain pandas... Enjoy! science.org/doi/10.1126/sc…

Extremely happy to share that our work on how #antibiotics usage long time ago can impair #gut #mucus function through the #microbiota is now published in Gut Microbes Taylor & Francis Research Insights! tandfonline.com/doi/full/10.10…

Combined with the preprint from Shai Bel, more evidence associating antibiotics usage with disrupted colonic mucus barrier function, worrying stuff...

🚨🚨News from MucinGlycoLab🚨🚨 - New insights into how the intestinal epithelial sialome protects from spontanous colitis, mucositis, and tumor development: We uncover unexpected roles of sialylation in impacting b1 mucus functions, the microbiota, and the stem cell niche!

Now out at #GutMicrobes, our work on Group B Strep in the neonatal intestine tandfonline.com/doi/full/10.10…

Please retweet: Vaishnava Lab MMI_Brown is looking for a post-doctoral fellow. Details of the position and application link: apply.interfolio.com/150992

I am incredibly happy to announce that I will set up my group on Epithelium-Microbiota Crosstalk ETH Zürich this fall 🤩 We will be hosted by the brilliant Emma Slack #IStandWithUkraine Lab, so excited to get started! I am recruiting a PhD student, pls share tinyurl.com/5f3dku94 yEFIS Swiss Young Immunologists Society (SYIS)

🦠📷 OUT NOW! Non-canonical start codons in carbohydrate utilisation operons provide context-dependent advantages for commensal E. coli by Yassine Cherrak, Wolf-Dietrich Hardt and colleagues nature.com/articles/s4156…

Microbiota-*independent* negative impact of antibiotics on the colonic mucus barrier, and an interesting link between abx use and susceptibility to #IBD. Nice work from the Bel Lab Science Advances