Loke and colleagues quantify the relative and interactive contributions of genetic and environmental influences on heterogeneity in immune profiles and helminth susceptibility. Read it here: rdcu.be/dKPrZ nature.com/articles/s4159…

Thrilled to share our latest work in nature in collaboration with the Davis Group at Rosalind Franklin Institute & Oxford Chemistry. We developed a 'cap & glycosylate' strategy that directly transforms native sugars into glycosides & glycoproteins! NUS Chemistry #glycotime nature.com/articles/s4158…

REVIEW Nature Reviews Bioengineering Engineered polysaccharides for controlling innate and adaptive immune responses nature.com/articles/s4422…

Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.

Nasal mucosa of children is characterized by often asymptomatic viral and/or bacterial infections that regulate distinct innate immune programs JExpMed Ellen Foxman Timothy Watkins preview Ivan Zanoni: doi.org/10.1084/jem.20… doi.org/10.1084/jem.20…

I am excited to share the results from my postdoc with Jonathan Kagan on the detailed characterization of the cell biology underlying Toll-like receptor (TLR) signaling in innate immune cells, published today in nature: nature.com/articles/s4158… Here’s a thread with our key findings 👇

The first tumor infiltrating lymphocytes (TILs) were FDA approved to treat refractory cancer (melanoma) this year. In the new issue Science Magazine a rundown and perspective from the pioneer who worked on developing this living drug for >30 years science.org/doi/10.1126/sc…

In this month's interesting fact about #glyco we learn how #monosaccharides not synthesized by humans/mammals could occur as part of the human/mammalian glycan repertoire. Read more: research.bidmc.org/ncfg/blog/fact… For more interesting facts check: research.bidmc.org/ncfg/interesti… #glycotime

Hoy recibimos el Registro Sanitario de Quimi-Vio, nuestra #vacuna antineumocócica conjugada, por el CECMED. En el Instituto Finlay de Vacunas, hemos trabajado en esta vacuna durante más de 15 años.¡Felicidades a investigadores e instituciones que han sido parte de esta bonita historia! 👏🎉

If you are convinced that microbes are causal of infectious diseases, please take a breath, and consider the alternative possibility that infection with a trigger microbe reveals a preexisting cause of disease in the host: annualreviews.org/content/journa…

Nature research paper: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan go.nature.com/3WsaD1S

IL-11 is a cytokine induced with age, regulates an ERK–AMPK–mTORC1 axis which contributes to age-associated tissue decline (Inflammaging). Blocking it show health benefit in aged mice. Beautiful new work by Stuart Cook lab & collaborators at MRC Laboratory of Medical Sciences (MRC LMS) nature.com/articles/s4158…

"Host control of the microbiome: Mechanisms, evolution, and disease" Science Magazine science.org/doi/10.1126/sc…

Check out our latest review on glycomics in host-response. Congratulations Ifthiha Mohideen on a great job! #glycotime Infection and the Glycome─New Insights into Host Response | ACS Infectious Diseases pubs.acs.org/doi/10.1021/ac…

Brainwashing. We're learning more about how the glymphatic system achieves waste removal from the brain and preserves immune response (such as surveillance) integrity science.org/doi/10.1126/sc… Science Magazine by Jonathan Kipnis 💔

The World Health Organization has updated its list of most dangerous viruses and bacteria go.nature.com/46uc8jy

Humans are locked in an arms race with microbes, but scientists are pursuing diverse approaches to keep one step ahead or slow down the competition. go.nature.com/3yCG2FX

BCG vaccination alters gene expression and chromatin accessibility in hematopoietic stem and progenitor cells, predicting cytokine secretion in peripheral blood mononuclear cells Immunity Luis B Barreiro Sarah Sun cell.com/immunity/fullt…

Budding scientists inherit career success—or the lack of it—from their mentors | Science | AAAS science.org/content/articl…

What is the difference between adaptive and innate immunity? I'm rethinking the adaptive immune lectures for my introductory immunology course and it got me thinking. I see three main properties and a few that no longer make the list. Here's a 🧵 What do you think?