Our April cover ➡️ hubs.la/Q02r6l130 shows overlayed temporal projection of actomyosin dynamics in the leading edge of migrating mouse embryonic fibroblast expressing EGFP-non-muscle myosin & mScarlet F-Tractin. From Melissa Quintanilla, Jordan Beach et al. hubs.la/Q02r6jGp0

I’m proud to have studied #KidneyCancer in my career. A recent discovery (with Frank Mason Vanderbilt University Medical Center) shows a new way to think about genomic instability in cancer, due to mutation in SETD2. #KidneyCancer AwarenessMonth go.nih.gov/AXyMSh3

Melissa Wolf Vanderbilt Health is studying the relationship between infiltrating immune cells and #RenalCellCarcinoma cells. medschool.vanderbilt.edu/igp/person/mel… #KidneyCancerAwarenessMonth

The deadline for Forbeck Scholar applications is fast approaching (March 18). Great opportunity for postdocs and early-career PIs to attend a Forum on a specific topic and then annual scholar retreats with colleagues at similar career stages.

Apply here: forbeckforums.org/scholar-award

Congratulations to newly minted Dr. Melissa M Wolf ! Co-mentored with Kimryn Rathmell in Vanderbilt-Ingram Cancer Center, we're proud of what you've done and excited for the next steps!

A potential role for centromere dysfunction in Down syndrome! We generated the first complete sequence of all three chr21 centromeres in an individual with Down syndrome & found that one centromere is ~11-fold smaller than usual and another has an atypical epigenetic landscape!

Want to learn more about RNAseq as a predictive biomarker in oncology trials, especially our #OPTICRCC trial in #kidneycancer ? Brian Rini, MD Katy Beckermann Vanderbilt Hem / Onc Vanderbilt-Ingram Cancer Center Register for this webinar: go.tempus.com/ls-the-value-o…

#1 Happy to share our work “Specialized replication mechanisms maintain genome stability at human centromeres” Molecular Cell from A. Scelfo, A. Angrisani and T. Wilhelm Institut Curie CNRS 🌍 where we provide the causes of centromere fragility.
authors.elsevier.com/a/1iba63vVUPRl…

📢New paper out in Genetics Society of America Genetics!
Congrats to postbac Jovan et al. - big collab with Emory Urology clinicians & researchers, who ID'd a SNP in RCC patients within SETD2, a known RCC gene. We made a 🪰 to study the SNP in the homolog, Set2.

📢📢 Applications are now open for 2024 Forbeck Foundation Scholars!

If you are interested in genomic instability in cancer, please consider applying to attend our upcoming meeting as a Scholar. We have a fantastic line-up of speakers so far.

Details here: forbeckforums.org/scholar-award

Many thanks to J Cell Science for publishing our at a Glance article about CIN and evolution. Congrats Andréa Tijhuis ERIBA Research UMCG and many thanks to KWFKankerbestrijding for funding.

Thanks to Brian Rini, MD and the AKCI for the opportunity! Great to connect/ reconnect/interact with so many great RCC researchers including Peter Ly and Abhishek Chakraborty.

Frank Mason AKCI lecture on SETD2 in RCC! youtu.be/ZK21kel2_K4?si… via YouTube

To close 2023, we present our work on #osteosarcoma genome and clonal evolution biorxiv.org/content/10.110… How does #osteosarcoma arise? What rearrangement mechanisms cause some of the most complex #chromothripsis events seen in human cancer? Does chromothripsis occur subclonally?👇

We wrote this review to put a metabolic spin on my favorite paper of all time--Martin Raff's 1992 piece in Nature on Social Control of Cell Survival and Death. Nutrients and metabolic signaling hold it all together.

sciencedirect.com/science/articl…

Kimryn Rathmell stepped down as chair of VUMC Department of Medicine & gave up her office, so I gave her a desk in my lab w/ the grad students. She's settled in & hard at work getting ready for the National Cancer Institute.

A year ago today I first posted a tweet a day for the month of December about how, despite the many issues, a life in science is impactful and fun. Here's a reposting of short essay about the many good things to remind ourselves & encourage others

Interested in how mitotic errors trigger micronuclei, #chromothripsis (chromosome fragmentation), and cancer genome instability? Check out our latest review Molecular Cell written by the talented duo of Alice Mazzagatti and Justin Engel.

TL;DR below (1/6):
cell.com/molecular-cell…

#Cancer impacts every family and community, and it is time to #EndCancerAsWeKnowIt . My family and I have been overwhelmed by the support in the wake of this announcement whitehouse.gov/briefing-room/… – thank you! I was at a loss for words, but I decided to share a 🧵: 1/

Couldn't be more proud of our fearless Chair, Dr. Kimryn Rathmell, who has been appointed Director of the National Cancer Institute! We wish you all the best in your new role as Dr. Kimryn Rathmell!

Read the official press release from the The White House here: bit.ly/46mI73s