Potential mechanisms driving the increased risk of cardiovascular comorbidities in patients with COPD reader.ersjournals.com/copd-in-the-21… ERS publications

Factors to be considered when defining COPD. Healthy ageing and/or exposure to risk factors may lead to development of symptoms such as breathlessness and/or to pre-COPD. Other medical conditions may also lead to symptoms. Pre-COPD may progress to COPD or may resolve.

Recent large-scale genetic epidemiology studies have identifed associations between genetic variation, lung function and individual respiratory diseases. This figure shows key genes and pathways implicated by GWASs of lung function nature.com/articles/s4157… nature

27% of patients diagnosed with COPD do not exhibit the diagnostic criteria of GOLD. Instead, 13% have normal spirometry (pre-COPD) and 14% PRISm. Yet their disease burden and temporal progression is similar to that of those with spirometrically confirmed GOLD 1–2 COPD

Putative explanation by which increased physiological dead space (wasted ventilation) and alveolar hyperventilation may trigger exertional dyspnea in patients with COPD doi.org/10.1080/154125…

Meta-analysis of 65 945 individual COPD patients demonstrates substantial differences in post-discharge mortality rates between countries. Global standardisation of management and follow-up of ECOPD-related hospitalisation should be a priority. openres.ersjournals.com/content/10/1/0…

People living with COPD are much more likely to be hospitalized with community-acquired pneumonia (figure). Bacterial colonization, airway inflammation, impaired host immunity and among predisposing factors. doi.org/10.4046/trd.20…

Started this Tuesday with learning about a 'new' syndrome in COPD: 'deventilation syndrome', or acute dyspnea immediately upon conversion from nocturnal noninvasive ventilation to subsequent spontaneous breathing during the day. Much remains unknown... karger.com/res/article/10…

Laboratory study shows that inhalable textile microplastic fibers, mainly from nylon, harm developing airways and/or airways undergoing repair ATS Blue Journal doi.org/10.1164/rccm.2… #microplastics #lunghealth

Patients with rheumatoid arthritis (RA) have increased risk of developing COPD, especially those with seropositive RA. Thus, clinicians should monitor respiratory symptoms and pulmonary function when managing patients with RA. CHEST doi.org/10.1016/j.ches…

Interested in the latest insights into pulmonary rehabilitation? Sign up for the online and/or on-site ERS academy: ersnet.org/events/academy…

Precision approach in the treatment of COPD exacerbations as presented in the Spanish guidelines in 2022.

Patients with pre-COPD with emphysema show significant small airway loss and remodeling on CT and micro-CT atsjournals.org/doi/10.1164/rc… ATS Blue Journal

Immunomodulatory actions of azithromycin in the respiratory system. Figure from the PhD thesis of Iwein Gyselinck, which he'll be defending today in Leuven

The clinical interplay between cardiovascular disease and COPD, highlighting the cardiopulmonary at-risk patient population in primary and secondary care doi.org/10.1093/eurhea…

Secondhand smoke exposure increases the risk of multiple health outcomes, including lung cancer, COPD, asthma and lower respiratory infections. Thus, public health policies and education initiatives are warranted to reduce passive smoking. nature.com/articles/s4159…

Smoking cessation makes sense: substantial drop in risk of cardiovascular, cancer and respiratory mortality among quitters compared to current smokers. However, it takes decades for risk to normalize to level of never-smokers (Figure). Source: doi:10.1001/jamainternmed.2023.6419

Nutritional and pharmacological treatments combined with exercise training and their effects on exercise capacity, muscle mass, maintenance and growth, and weight loss in COPD mdpi.com/2072-6643/15/2…

Reported effects of vaping and e-cigarettes on the human pulmonary system. Review from 2019, but still very relevant and informative. The BMJ bmj.com/content/366/bm…

Pooled analysis of case-control studies provides robust evidence for association between occupational benzene exposure and increased lung cancer risk. Thus, exposure at unregulated workplaces and in low and middle-income countries remain of great concern. doi.org/10.1164/rccm.2…