We are very excited to share our preprint out now in bioRxiv lead by Divya Jha!! We describe how epithelium-associated myeloid cells in ulcerative colitis impact response to anti-TNF therapy Lipschultz Precision Immunology Institute Mount Sinai Division of Gastroenterology Icahn School of Medicine at Mount Sinai biorxiv.org/content/10.110…

T cells primed in the gut influence immune responses to extraintestinal tumors Devaud Christel Virginie Feliu Carolina Alves Costa Silva, MD, PhD Kroemer Zitvogel Ayyoub Gómez-Roca Fidelle Rauber lisaderosa science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

The PM really does need to understand that he is now further damaging U.K. science by not immediately rejoining Horizon, presumably to placate some know-nothing fringe bloviators who know nothing about science, its value or how it’s conducted. As Lord Rees says below, it is

Conducting metagenomic analysis of the #microbiomes of 440 adults, researchers define how shifts in microbial taxa and metabolic pathways correlate with inflammatory conditions such as rheumatoid and psoriatic #arthritis. Curtis Huttenhower Harvard Biostatistics scim.ag/3vT

Knight Lab (UC San Diego School of Medicine / UCSD Engineering) is excited to announce a new release of Greengenes in Nature Biotechnology (nature.com/articles/s4158…). With this release, we provide a single taxonomy and phylogeny unifying 16S and shotgun metagenomic analyses! A thread (1/n)

Today we report a detailed map of interactions between the immune system and the gut microbiome. Kazuki (Kaz) Nagashima led the charge w/ help from Aishan Zhao and Kat Atabakhsh. nature 1/40 nature.com/articles/s4158…

One man's niche is another man's treasure 😀

.Yi Yang & Cadwell Lab discuss work from Dr. Hiutung Chu 朱曉彤 @chulab.bsky.social (bit.ly/3v1Yh5k) revealing that commensal bacteria elicit tonic type I interferons to prime dendritic cells and induce regulatory T cells that maintain a tolerogenic intestinal milieu. bit.ly/3RonjDu

OUR LATEST ARTICLE HAS BEEN PUBLISHED 🎉 Read our study ‘Antibiotic Use in the 12 months Prior to Ileal Pouch-Anal Anastomosis Increases the Risk for Pouchitis’ here ➡️ pubmed.ncbi.nlm.nih.gov/38556033/ Edward Barnes MD MPH Karachalia Sandri Anastasia #HansHerfarth Tine Jess Danmarks Grundforskningsfond Aalborg Universitet

Microbiota therapeutics for inflammatory bowel disease: the way forwar... sciencedirect.com/science/articl…

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

We have enrolled the first patient in the pivotal Phase 3 study of VE303 for the prevention of recurrent C. difficile Infection. To our knowledge, this is the 1st registrational study of a Live Biotherapeutic Product for rCDI An important milestone in our field /1

⌛️Starting in 10 minutes! 🤩Learn about cardiovascular risk assessment in IBD from the world expert Edward Loftus 🔗Not yet signed up? bit.ly/Global-IBD-VP-… ✅Summary incoming🧵 Miguel Regueiro Stefan Holubar MD MS David Liska Scott R. Steele Fernando Gomollón Y-ECCO iris dotan

Every year, Jean-Frederic Colombel hosts the GI Division #IBD Retreat to address challenging topics in #IBD. We're proud to keep the tradition going this year at IBD Retreat 2024! Register here to join: form.jotform.com/kalish39/IBDre…

Wow, @nature has retracted the 2020 Poore et al. cancer microbiome paper that we showed (journals.asm.org/doi/10.1128/mb…) was deeply flawed. The retraction date is tomorrow so I can't yet read the official notice, but I'll update when I can Retraction Watch Professor Booty PhD

Out now 🚨 in Gastroenterology is your latest update on selective IL-23p19 inhibition in IBD! Amongst other topics featuring discussion of pathogenesis, PD/PK, efficacy, safety, positioning, and more! Together with Jean-Frederic Colombel Mehandru Lab @MountSinai & Ryan Ungaro MD MS gastrojournal.org/article/S0016-…

Sir Patrick Vallance KCB has been appointed Minister of State (Minister for Science) in the Department for Science, Innovation and Technology Department for Science, Innovation and Technology.

A scientist. As minister for science. Shouldn't be surprising or notable, but this heartens me as much as anything else i have seen in the last 24 hrs (speaking as someone who grew up in Liz Truss’s former constituency). 🇬🇧

Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity | Nature Cell Biology Yet another example of gut immune-imprinting for functions beyond the gut #InGutWeTrust nature.com/articles/s4155…

Age-related patterns of microbial dysbiosis in multiplex #IBD families 🔖 The BMJ 👥Jacobs Lab Elizabeth A Spencer MD MS Graham Britton Joana Torres Jean-Frederic Colombel Jeremiah Faith Marla Dubinsky et al gut.bmj.com/content/early/…