Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics | Journal of the American Chemical Society The Florey Science at Melbourne University of Melbourne #Peptide #Stapling #Helical #Peptidomimetics pubs.acs.org/doi/10.1021/ja…

🧬A cutting-edge discovery from The Florey's HossainLab has solved a long-standing problem in peptide based drug development - paving the way for new treatments in a range of conditions. Find out how our researchers solved the floppy peptide problem: florey.edu.au/news/2023/07/n… 👇

Peptides, smaller relatives of proteins, have therapeutic potential - but without proper structure become floppy and inactive. Florey researchers simplified ‘peptide stapling’, turning a multi-step process into a single-step one. Access J. Am. Chem. Soc. paper: doi.org/10.1021/jacs.3…