.Penn Medicine scientists show that ILC1s are a tissue and circulating biomarker that distinguishes #sarcoidosis from other skin granulomatous diseases. 💡 Dig into the details: bit.ly/3MEDXwp

Deadlines are approaching for Keystone Symposia #MyeloidCells: Roles in Different Tissue #Microenvironment, this March in Hannover! See scholarship, abstract and discount reg dates: keysym.us/KSMyeloid25 #KSMyeloid25

Explore the dual role ↔️ of CD177 + neutrophils in inflammatory bowel disease (#IBS) this weekend. Check out this from authors based out of Shanghai University of Traditional Chinese Medicine! ✔️ bit.ly/4dT8ZNl

To gain insight into how an adjuvant impacts vaccination responses, NIH scientists used systems immunology to study human H5N1 influenza #vaccination 💉 with or without the adjuvant AS03. 📖 Discover their study findings: bit.ly/4geTrVw

Congratulations to Tobias Kammann and team, including Johan K. Sandberg, on their recent Science Immunology paper! 👏 They show functional heterogeneity and tissue site adaptation in resident MAIT cells across human barrier 🛡️ tissues with distinct regulatory and effector signatures.

Learn about skin recurrence in #BreastCancer. Scientists found that the immune microenvironment of skin lesions might be in a state of suppression, and as the disease progressed, the state of immune suppression in the skin lesions might intensify. 📌 bit.ly/3Tn4UZj

CD3+ and CD8+ nTILs are associated with pathological response and 5-year RFS in melanoma patients after neoadjuvant anti-PD1 therapy, reported Penn researchers in this Clinical Cancer Research study. 💡 Learn more: bit.ly/3Tkoh5y

🔥 Introducing ISB 2001! ISB 2001 is a trispecific T cell engager with the potential to induce deep responses in patients with r/r #MultipleMyeloma. 💡 Learn more in Nature Cancer: go.nature.com/4em58rI

Researchers show that PRMT3 expression is induced by immune checkpoint blockade-activated T cells via an IFNγ-STAT1 signaling 🚥 pathway. Higher PRMT3 expression levels correlate with reduced numbers of tumor-infiltrating CD8+ T cells. go.nature.com/3AW9uaE

Scientists discuss the role of altered #BoneMarrow microenvironments in the induction of immune dysregulations that accompany #myeloid malignancies. 🔗 Discover more: bit.ly/3zhXqQF

In this CDD press study, scientists from Central South University report that CD4+ T cells from acute type A aortic dissection patients presented with a hypofunctional phenotype that was correlated with poor outcomes. 👉 go.nature.com/4d3EkLV

Collaborators showed that exposure to S100A9 and HMGB1 converted healthy donor-derived #monocytes into myeloid-derived suppressor cells through toll like receptor 4 signaling. 🚦 🔗 bit.ly/3ztZntf

Deadlines are approaching for Keystone Symposia #CancerImmunotherapy: Clinical Lessons to New Modalities, this March in Banff! See scholarship, abstract and discount reg dates: keysym.us/KSCancerImmune… #KSCancerImmune25

.Peter Mac Cancer Centre researchers, Nicole Haynes, Tom Chadwick, & Belinda Parker (Belinda Parker) explore the complexities of immune escape mechanisms used throughout the metastatic cascade to promote tumor cell dissemination and affect organotropism. ✔️ go.nature.com/3Tyf09T

Deadlines are approaching for Keystone Symposia Immune #CellTherapy: Advances in #Cancer and #AutoimmuneDisease, this March in Banff! See scholarship, abstract and discount reg dates: keysym.us/KSCellTherapy25 #KSCellTherapy25

Cell therapy with modified peripheral blood-derived PD-1+ T cells is both safe and effective 👍, reported a Zhengzhou University research team. 💡 Find out about the study design and findings: bit.ly/3XQmBU4

Join MIT Dept of BE as an Assistant Professor in immunology, immunotherapy, & immune engineering. Check out the job posting! 👇

In patients with variants in the GNAI2 gene, researchers found enhanced suppression of effector cAMP generation and established a pathogenic role of chronic decoupling of active Gαi2 from GPCR for impaired #leukocyte migration. NIDAnews 👉 bit.ly/3XznmPF

Dr. Andrew Sewell's team (T-cell Modulation Group) and collaborators provide a mechanism by which molecular mimicry between pathogen and self-antigens could have resulted in the breaking of self-tolerance to initiate disease. 😷 Journal of Clinical Investigation | bit.ly/3TE45eR

Scientists show viral infection to be characterized by a distinct signature of decreased interferon signaling and lower interferon receptor gene expression. 🦠 📖 Read the full study in Nature Communications: go.nature.com/3BdlKUn