Happy to share latest preprint on plasma FIB milling! We characterise the use of xenon to prepare lamella from HPF samples, with numbers generated on a par with cells on grids! Take a look! Congrats to Casper and Helena Helena Watson for their heroic efforts! Rosalind Franklin Institute

Check out our new preprint! Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry – a perspective. biorxiv.org/content/10.110…

Our porcine deltacoronavirus paper is now online Nature Communications 🎉 nature.com/articles/s4146… A huge congrats to co-first authors Wenjuan Du/Oliver Antoniak, and everyone else who contributed. This was another great collaboration with the Bosch group - stay tuned for the next one!

Meet the speakers #PRPconference | Daniel Hurdiss from Utrecht University will be in Trieste to talk about his studies of #coronavirus spike proteins and the value of structural biology to provide insights into cell entry mechanisms and immune evasion. More: bit.ly/3x6HcIt

📢 Registration for our upcoming Wellcome/MRC single particle #CryoEM course for the beginners is now open! Join us in person at the Astbury Biostructure Laboratory The Astbury Centre University of Leeds Click the link for details and registration! 🌟 astbury.leeds.ac.uk/facilities/wel…

The result of our very first intentional milling by Yehuda Halfon 🏳️‍🌈 and Joshua White with the new Hydra Bio PFIB-SEM on polished silicone! 😍📷 #FIBSEM #CryoEM

Look🤩, the new Microscopy & Spectroscopy Arctis #PFIB Max Planck Institute of Biophysics has done its first thing. Not #cryoEM yet, but we're kind of excited anyway.

Online now! Structural basis for the inhibition of βFXIIa by garadacimab dlvr.it/TB3fj0

The peer-reviewed version of our garadacimab manuscript is now online Structure! Link to the article: authors.elsevier.com/c/1jUWp3SNvcAb… #cryoEM #antibody #epitopemapping

Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headlines in this video: cell.com/cell/fulltext/…

The journal BBRC has a problem with inadequate reviewing of cryo-EM maps and models: pubpeer.com/publications/D…

Frizzled receptors are essential for all multicellular life, from hydra to humans. Please check out our new paper on how we used nanobodies to elucidate the structure and function of Frizzled 3: nature.com/articles/s4146…

I dare say, this is probably single most accomplished contribution to plant structural biology field in at least a decade. Back to back Cell papers by Zhen Yan lab Westlake University report structures of a plant chloroplast import complex TIC-Ycf2-FtsHi & algae Ycf2-FtsHi.

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens nature.com/articles/s4146…

We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

I’m delighted to be among this year’s recipients of the ERC Starting Grant! This funding will allow my group to take a deep dive into the replication and assembly mechanisms of positive-strand RNA viruses. I'm particularly excited to expand our in situ #cryoET capabilities!

Cryo-EM is a bit of an imaging miracle. We collect 2D images with stupid amounts of noise. We don’t know what we’re looking at, or from which way. Yet some how we can churn it over and get to see (actually see) how life works on molecular scales in 3D. How?