Now in Science Immunology: Hongbo Luo & al. (Harvard Medical School) report #palmitoylation of #GasderminD (#GSDMD) @ C191/C192 controls its membrane localization & activation! Tx w/ palmitoylation inhibitor alleviates #sepsis in mouse models! #pyroptosis #inflammasome bit.ly/SciImm_adn1452

The April issue of Science Immunology is here! This week: a #twin study delineates #uterine #ImmuneSystem variation, #MIZ1 ensures IgG1+ GC #Bcell survival in + selection, & AS03 #adjuvant enhances #memory B cell responses in plant-based #COVID19 #vaccine! science.org/toc/sciimmunol…

To celebrate the AACR's annual meeting (#AACR2024), Science Immunology has just released a sample collection of some of our recent #CancerImmunology & #CancerImmunotherapy research articles! Articles are free online to read until the end of June 2024! bit.ly/SciImm_free

In Science Magazine, Liang Chi, Belkaid Lab, & colleagues report #SexDifferences in #skin #immunity regulated by an #androgen–#ILC2–#DC axis! With Perspective by Lloyd Lab NHLI & Franz Puttur! RA: bit.ly/sci_adk6200 PS: bit.ly/sci_ado8542

In The Scientist, Nathan Ni uses a recent Science Immunology paper by Lilit Grigoryan, Yupeng Feng, Pulendran, & al. to show how constructing a narrative is crucial to effective scientific writing: bit.ly/3JopEKT See also: Grigoryan & al (2024)! bit.ly/SI_adi8039

'Tis the season! Happy International #DayOfImmunology from the editors at Science Immunology!

The May issue of Science Immunology is out! This week: how #Th17 cells mediate #steroid resistance in #neuroinflammation; #OXPHOS → #BCell #cytokine secretion in #MS; & how #NKCells recognize & target activated #TCells to impede #cancer #immunotherapy bit.ly/SciImm_9_95

Now in Science Immunology: Vacchini, De Libero, &al report #carbonyl adducts of #nucleobases are #SelfAntigens presented by #MR1 that activate #MR1TCells! Detecting altered #metabolism may allow #ImmuneSystem to perceive changes assoc w/ #infection & #cancer! bit.ly/SciImm_adn0126

Now in Science Immunology: HUST researchers analyze #blood & #CSF from patients w/ #neurological #autoimmune disease (#NMOSD) undergoing #CARTCell therapy. These CAR T cells show differences w/ CAR T cells from treated #myeloma & #lymphoma patients! bit.ly/SciImm_adj9730

The June issue of Science Immunology is out! This week: • #lymphatic transport's role in LN-resident #TRMcell formation • #PlasmaMembrane abundance regulates #myeloid cell #phagocytosis • tracking #γδTcells across the entire #human lifespan! bit.ly/SciImm_9_96

In work featured on this month's cover of Science Immunology, Josh Gray, Donna Farber &al. analyzed the phenotype, transcriptome, function, & repertoire of #GammaDeltaTcells in blood & mucosal & lymphoid tissues from 176 #human donors across the life span! scim.ag/7fr

Great stuff in this week's issue of Science Magazine!

After a wonderful day of lab visits at Trinity College Dublin, I'm now off to the opening session of the Sex Differences in the Immune System meeting in Dublin! Tá mé ag tnúth leis! (I'm looking forward to it!)

To celebrate the FOCIS annual meeting (#FOCIS2024), Science Immunology has just released a sample collection of some of our recent human #immunology & #immunotherapy research articles! Articles are free online to read until the end of August 2024! bit.ly/SciImm_free

Controlled experimental infections with #Schistosoma mansoni reveal how the human #immune response to #schistosomiasis changes over time. Read this research and more in the July issue of Science #Immunology: scim.ag/7zC

Now in Science Immunology: CrowLab & Casanova Lab #review the #human monogenic disorders underlying insufficient & excessive type I #interferon signaling. These disorders may inform prevention & treatment of #viral & #inflammatory #diseases! #IFN #PID bit.ly/SciImm_adm8185

In Science Immunology this week, Emma Louise Houlder, Koen Stam, Maria Yazdanbakhsh, Meta Roestenberg, & al. at LUMC Parasitology track how immune responses evolve over time in #schistosomiasis using controlled #Schistosoma mansoni infections of human volunteers! bit.ly/SciImm_adl1965