Our NEW issue is now live! Read it here: go.acs.org/aCT Front cover story by Stache Lab go.acs.org/aCU

Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids? NEW #FirstReactions by Marta Filizola discussing work by Susruta Majumdar & colleagues go.acs.org/aCS Read it here: go.acs.org/aCR

#ICYMI Nucleoside salvage and cathepsin nuclear translocation are leveraged in design of a lupus antinuclear antibody-drug conjugate as a DNA-seeking and tumor agnostic “antinuclear missile” cancer therapy By James E. Hansen & team Yale School of Medicine Read it here: go.acs.org/aDS

Can Diabetes Drugs like Ozempic Tackle the Mental Health Crisis? NEW #HUB in collaboration with C&EN (Chemical & Engineering News) Read it here: go.acs.org/aDT

A facile sample handling and transfer procedure enabled the crystal structure determinations of highly reactive xenon compounds by 3D electron diffraction on nanometer-sized crystals NEW #ASAP by Matic L⌬zinšek Electron Crystallography Prague Read it here: go.acs.org/aFK

Uncovering the Absolute Structure of the Malarial Pigment Crystal, Hemozoin, Using Cryo-electron Tomography and Three-Dimensional Electron Diffraction NEW #FirstReactions by Shyamal Mosalaganti discussing work by Elbaum, Leiserowitz & team Read it here: go.acs.org/aGE

How Japan Took the Lead in the Race to Discover Element 119 After a breakdown in US-Russia relations, Riken finds itself ahead of its rivals. And LBNL chases element 120 NEW #HUB in collaboration with C&EN (Chemical & Engineering News) Read it here: go.acs.org/aHw

#ICYMI Our NEW issue is now live! Read it here: go.acs.org/aHx Supplementary cover story by You Yang & team #ECUST go.acs.org/aHy

The C−H silylation of methyl groups in complex terpenoids unlocks diverse transformations, including elimination, substitution with other functional groups, and integration into an expanded ring NEW #ASAP by The Hartwig Group Read it here: go.acs.org/aIK

Asymmetric Three-Component Radical Cascade Reactions Enabled by Synergistic Photoredox/Brønsted Acid Catalysis: Access to α-Amino Acid Derivatives NEW #ASAP by Chun-Jiang Wang, Xiaotian Qi & team #WuhanUniversity Read it here: go.acs.org/aJP

Nickel-catalyzed enantio- and diastereoselective hydroalkylation of fluoroalkenes is developed to give enantioenriched organofluorine compounds bearing adjacent stereocenters NEW #ASAP by Xile Hu 胡喜乐 Read it here: go.acs.org/aLA

STING-activating polymer−drug conjugate, SAPCon, prolongs drug circulation and enhances tumor accumulation of a novel diABZI agonist to promote antitumor immunity NEW #ASAP by Immunoengineering Lab Read it here: go.acs.org/aME

A comprehensive approach to track polymer chain evolution during deconstruction was developed and revealed the influence of deconstruction method and polymer architecture on product distributions NEW #ASAP by Epps Group LaShanda Korley & team Read it here: go.acs.org/aNF

#ICYMI Our NEW issue is now live! Read it here: go.acs.org/aNI Supplementary cover story by Vicki Wysocki Jared B. Shaw & colleagues go.acs.org/aNH

Highly regio- and stereoselective hydrosulfuration of ynamide bearing a strong electron withdrawing group has been identified as an efficient tool for peptide and protein cysteine modification go.acs.org/aOA NEW #ASAP by Junfeng Zhao, Norman Metanis, Xiaobao Bi & team

C−H labeling methods for PET rapidly incorporate fluorine-18 using stable precursors with minimal prefunctionalizations. This improves access to radiomedicines, enhancing bioimaging and drug discovery go.acs.org/aPq NEW #OUTLOOK by ScottLab Sanford Lab & team

Domain-structured LiMnO2 with large surface area has been synthesized & proposed as Co/Ni-free positive electrode materials with high-energy density for practical Li-ion battery applications go.acs.org/aR6 NEW #ASAP by Naoaki Yabuuchi & team #YokohamaNationalUniversity

Simultaneous engineering of cavity & window within quasi-discrete pore structure in metal−organic frameworks enhances thermodynamic & kinetic separation of 4-methyl-1-pentene from its isomers go.acs.org/aS1 NEW #ASAP by Zongbi Bao, Kai Qiao & team #ZhejiangUniversity

He et al. present COF-supported palladacycles for sustainable C–H arylation of indoles and pyrroles, with high catalyst reactivity and recyclability NEW #ASAP by HeLab_HKU HKU Chemistry HKU_Science Read it here: go.acs.org/aSZ

#ICYMI Our NEW issue is now live! Read it here: go.acs.org/aT2 Supplementary cover story by James E. Hansen &colleagues Yale School of Medicine go.acs.org/aT1