Great new tool set for taxonomic profiling of long read #metagenomic datasets, including PacBio HiFi reads! I'll be following this one closely🧐

The interplay between diet and the gut microbiome: implications for health and disease rdcu.be/dNWyv Stanton & co. examine the effects of different whole diets on the gut microbiome and explore how they influence human health and the progression of chronic diseases.

I’m happy to say that we’ve just released a manuscript on bioRxiv describing our new tool TRGT-denovo. This new method was developed by Tom Mokveld and Egor Dolzhenko along with the help of many collaborators (1/n) biorxiv.org/content/10.110…

Interesting #metagenomic study showing prevalent chimerism in short-read MAGs, based on truth set of single amplified genomes (SAGs). No surprises here. Would love to see this repeated with long-read sequencing, which massively improves assembly... doi.org/10.1186/s40168…

Considering a short-read upgrade? Vote: What's the most compelling feature of the #Onso system for your research? See how Onso can boost your research and grab our exclusive trade-in offer. T&Cs apply. Details: bit.ly/4bSFmtL #PacBio

Ok! This is a special one! My last postdoc / first PI paper is out! 🥳 Stay with me if you are into: Defense Systems🛡️ Asgard Archaea⚡️ Origin/Evolution of Immunity💪🏽 rdcu.be/dPyF4 🧵(1/8)

Short-read #sequencing with #Onso continues to push the boundaries of genomic discoveries across diverse fields of research. Explore how the Onso Q40+ accuracy is unlocking new levels of precision and certainty in oncology, public health, and beyond. bit.ly/3ztRTpK

Why are we still trying to force short-read taxonomic classifiers and profilers to work with long-read #metagenomic datasets? There are over a dozen methods available now for long read taxonomic classification/profiling. We need to benchmark the relevant tools.

Discover how hifi long reads (PacBio) enable hundreds of contiguous MAGs in wetland soil microbiomes at #ISME19! Visit my poster PS1.25.025 to learn about PacBio vs. Illumina sequencing, higher quality MAGs, and recovery of circular ⭕️ genomes from bacteria and archaea 🦠.

Happy to introduce sawfish, a new HiFi structural variant caller emphasizing local haplotype modeling to improve SV representation and genotyping in both single and joint-sample analysis contexts: 1/n doi.org/10.1101/2024.0…

Sawfish: Improving long-read structural variant discovery and genotyping with local haplotype modeling biorxiv.org/content/10.110… 🧬🖥️ github.com/PacificBioscie…

This is a fantastic #microbial #research conference with a diversity of scientific content, held in a smaller venue. If you haven't attended before, it is 100% worth it.

If you study an endangered vertebrate species and plan on sequencing their #genome, this PacBio grant is for you! Looking at the #herpetology community on this one - plenty of endangered #reptiles and #amphibians to choose from! 🐸🐢🐍🦎