New preprint from the lab: A maternal-effect toxin-antidote element causes larval arrest in C. elegans, by Stefan Zdraljevic et al. biorxiv.org/content/10.110…

This is a truly beautiful story unveiling sexually-dimorphic developmental features! Brava Sara Formichetti and the entire Boulard team 👏👏👏🤩🤩🤩

Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new Royal Society Publishing biographical memoir: royalsocietypublishing.org/doi/10.1098/rs…

Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells biorxiv.org/content/10.110…

I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.110… 1/

Part 2 of my postdoc work is out! We show that the ploidy-to-cell size ratio is a highly conserved, “intrinsic” determinant of cell physiology. Check out the paper for more insight into how and why. Link - nature.com/articles/s4159… Free PDF – rdcu.be/dONo3 Also, a fun🧵!

We are delighted to announce our 2024 Reproductive Health and Science Research Fellows! With topics ranging from placenta accreta to menstrual stigma on social media, we have another incredible group of students and fellows this year. Stay tuned for more!

Recap and some details about Abyssal by Saskia Baden. Now up on CRSHE’s website❤️ Keep pushing. reprohealth.ucla.edu/2024/07/23/ucl…

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

Our new paper! mRNAs play structural roles in the cytoplasm. The longest mRNAs bound to FXR1 generate an mRNA-protein assembly that plays an essential role in cellular signaling by enabling proximity of proteins without RNA binding domains. cell.com/cell/fulltext/…

When you think about it, 300-400nm is really a large distance. We couldn’t fit the whole sphere representing the “permissive regulatory distance” in the figure! The arc on the right side shows how large a 400nm radius sphere is compared to the size of transcriptional regulators

Twitter I need your help! There is a book I’m trying to find about how machine learning algorithms “cheat” to achieve the tasks assigned to it. For instance a melanoma vs mole model detecting the presence of a ruler. I think it has a bright green cover. Any ideas? Thanks!!

Chromatin scientists, want to reorganize genomic loci as you wish? Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/…

📣review alert! How do enhancers activate promoters? Physical contact? Spooky action from a distance? read Peters' review (and thread!) for more... authors.elsevier.com/sd/article/S09…

Thanks to Viviane Callier 柯蔚文 for this nice write up covering our discovery of the cephalopod Z chromosome scientificamerican.com/article/the-ea…

Together with John Kim, we're teaching a Great Experiments in Bio class. I'm going to post each paper. I suggest checking them out. They span broad areas of bio. In the class, students provide a modern paper that is related to the classic paper. First up: nature.com/articles/28779…

Very helpful! But consider colorblind-friendly color palettes 🎨 ggpubfigs only supports colorblind-friendly color palettes, so it is something users don't even need to think about :D github.com/JLSteenwyk/ggp… x.com/tangming2005/s…

#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: doi.org/10.1152/physre… Yagya Chadha Arohi Khurana

📢📢New paper alert! The work of Aly, the first PhD student in my lab is out! We have explored the mechanisms of germline entry in the mouse and identified integrin signaling as a new roadblock of primordial germ cell specification. Keep reading: science.org/doi/10.1126/sc…

Interesting point! Looping brings enhancers and promoters 300-400nm apart, but we can measure distances of 50nm - why are they reproducibly this distance apart?