About the smile: the standing ovation also meant that people saw what I knew: behind every one of these bars is a patient. I know every name and have seen almost everyone. I know their stories and their children. And I believe many are cured because of this. #ESMO22 #ChalabiPlot

9 days left! Any questions feel free to DM or email me.

News— Drugging WRN in MSI-H Cancers. bit.ly/3VVy6sJ

Great to see two additional WRN inhibitors in addition the covalent inhibitors we recently reported ( aacrjournals.org/cancerdiscover…) in Cancer Discovery Very rewarding to see WRN inhibitors progress from their discovery (nature.com/articles/s4158…) and basic science to the clinic!

Nature research paper: Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo go.nature.com/4dbd3si

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase | Nature nature.com/articles/s4158…

Congratulations to Julio Saez-Rodriguez Saez-Rodriguez Group on becoming the new head of research of EMBL-EBI and congratulations to Jo McEntyre for the promotion to Deputy Director of EMBL-EBI. ebi.ac.uk/about/news/ann…

Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: kinase-library.mit.edu/home Wonderful collaboration with Cantley Lab Turk Lab YaffeLab. Many years of work led by Jared Johnson! nature.com/articles/s4158…

Congratulations Matt. This is really informative

Apply as a research group leader! Lead an independent research group in computational biology, focusing on AI-biology interfaces. Enjoy core support and outstanding infrastructure. Explore EMBL's Molecules to Ecosystems vision, and more! embl.org/jobs/position/…

Dreaming of leading your own research group in computational biology & bioinformatics? We’re recruiting two research group leaders, in particular working at the interface of AI and biology. We especially encourage women to apply as they’re under-represented on our faculty.

Happy that CellRank2 is out Nature Methods! Philipp Weiler & Marius Lange led this multimodal extension of CellRank, to allow study of cellular fate via multiview single-cell data of millions of cells in unified fashion. Text nature.com/articles/s4159… code github.com/theislab/cellr…

New in Gastroenterology Organoids for functional precision medicine in advanced #PancreaticCancer sciencedirect.com/science/articl… A prospective trial from Gustave Roussy Inserm on establishing patient-derived pancreatic cancer organoids & generating personalized treatment recommendations

Congratulations, Sir Tony! 🤩👇

Impressive work in Nature Genetics from the UK 100,000 Genomes Project: Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology nature.com/articles/s4158…

To fulfil the science at scale happening at the Institute, the Sanger has extended group leader one positions from six to eight years. The work, in collaboration with Wellcome, aligns with our mission of developing ambitious #genomics research. sangerinstitute.blog/2024/06/25/gro…

It is great to see our work published in this issue of Cancer Discovery and commented on by Zev Wainberg in the Spotlight section, discussing the clinical potential of developing WRN inhibitors! aacrjournals.org/cancerdiscover…

From the August issue: Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. bit.ly/3yN4ip3 Gabriele Picco Mathew Garnett Garnett Lab Wellcome Sanger Institute

Congratulations to Mamta Sharma on being shortlisted for the Outstanding Technician of the Year award! 🎉 Technician Commitment Garnett Lab