New work from Swathi Devireddy, a fantastic postdoc in my lab, showing an new mechanism controlling ER exit of progranulin and prosaposin. Important for secretory pathway, lysosomes and GRN-linked frontotemporal dementia. ⁦⁦Bluefield Project⁩ biorxiv.org/content/10.110…

It was amazing to read a commentary by Bruno Gasnier PNASNews on our newly published paper.

Check out this elucidative review on the endocytosis of nutrient transporters in fungi. sciencedirect.com/science/articl…

Happy to celebrate and share this new paper led by Swetha Gowrishankar in collaboration with De Camilli Lab and Yale Cell Biology colleagues on roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/mb…

We seek to hire a scientist to promote the use of induced pluripotent stem cells as a model for neurodegenerative disease research in a multilab collaboration. iPSC experience a plus but can train a motivated individual with cell biology experience. Please share. DM questions.

We’re back for #MicroscopyMonday! Human induced pluripotent stem cells that have been genome edited to tag their LAMP1 and LMNB1 genes with fluorescent proteins in order to visualize lysosomes (LAMP1-GFP) and nuclear envelopes (LMNB1-mTagRFP-T). Image by Agnes Roczniak-Ferguson.

This is an interesting new study that helps to explain how PQLC2 can perform dual functions as both a lysosomal amino acid transporter and sensor. It nicely complements our recent discoveries that PQLC2 recruits C9orf72 complex to lysosomes. pnas.org/content/118/32…

Do you wanna know more about the role of cytosolic tails for MFS transporters? Check out this interesting paper. biorxiv.org/content/10.110…

I am happy to announce that my last PhD paper was finally accepted in Journal of Cell Science journals.biologists.com/jcs/article/do…

What a great experience to publish in J Cell Science. If you are interested check out the final version of the manuscript and a first author interview. journals.biologists.com/jcs/article/13… journals.biologists.com/jcs/article/13…

Check out our 'First persons' interview with Cláudia Barata-Antunes and Gabriel Talaia Gabriel Talaia on their joint project Universidade Minho investigating trafficking of the en1 carboxylate transporter: ow.ly/anS850Ju8Ui

Here is our preprint that defines a new regulatory mechanism for mTORC1 at lysosomes. Led by Gabriel Talaia with contributions from Amanda Bentley-DeSousa. Yale Cell Biology biorxiv.org/content/10.110…

Lipid transfer from the ER by Vps13 proteins is a key part of the cellular response to lysosome damage - see new work from De Camilli Lab in collab with Shawn Ferguson: biorxiv.org/content/10.110…

Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition | The EMBO Journal embopress.org/doi/full/10.10…

Thrilled to see this work finally published The EMBO Journal thanks everyone Amanda Bentley-DeSousa Shawn Ferguson Yale Cell Biology Yale Neuroscience Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition | The EMBO Journal embopress.org/doi/full/10.10…

Congratulations to Gabriel Talaia and Amanda Bentley-DeSousa! I am happy to share our new study that identifies an amino acid regulated lysosomal pool of TBK1 that phosphorylates Rab7 and supports mTORC1 activation. doi.org/10.1038/s44318…

New research from Gabriel Talaia Amanda Bentley-DeSousa & Shawn Ferguson highlights a role for TANK-binding kinase 1 (TBK1) in lysosome homeostasis (alleviating Rab7-mediated inhibition of mTORC1 activation); May contribute to the pathogenesis of ALS-FTD embopress.org/doi/full/10.10…

Critical new insight into a role for TBK1 - an ALS-FTD disease gene - at lysosomes. Congrats to Gabriel Talaia Amanda Bentley-DeSousa from Shawn Ferguson lab! embopress.org/doi/full/10.10…

Lysosomal TBK1 responds to amino acid availability at the lysosome surface, to promote mTORC1 activation by relieving Rab7-dependent inhibition Gabriel Talaia Gabriel Talaia, Amanda Bentley-DeSousa Amanda Bentley-DeSousa, Shawn Ferguson Shawn Ferguson Yale Cell Biology embopress.org/doi/full/10.10…